Reactome | PIK3CA [cytosol]

PIK3CA [cytosol]

Stable Identifier

R-CFA-74787

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

PIK3CA, A0A5F4C2B1

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - RET signaling (Canis familiaris)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Regulation of T cell activation by CD28 family (Canis familiaris)
    - Co-stimulation by CD28 (Canis familiaris)
      - CD28 dependent PI3K/Akt signaling (Canis familiaris)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        PI3K binds CD28 (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
    - Co-stimulation by ICOS (Canis familiaris)
      - PI3K binds ICOS (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        ICOS:PI3K [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
  - TCR signaling (Canis familiaris)
    - Downstream TCR signaling (Canis familiaris)
      - PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        PI3K bound to TRAT [plasma membrane] (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
      - Recruitment of PI3K to plasma membrane (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        PI3K bound to TRAT [plasma membrane] (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
- Cytokine Signaling in Immune system (Canis familiaris)
  - FLT3 Signaling (Canis familiaris)
    - Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)
      - Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
      - PIK3CA [cytosol] (Canis familiaris)
    - Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)
      - PIK3CA [cytosol] (Canis familiaris)
      - active FLT3:p-Y GRB10:PI3K [plasma membrane] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-2 family signaling (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
      - 14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
      - Regulation of signaling by CBL (Canis familiaris)
        
        CBL ubiquitinates PI3K (Canis familiaris)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        K63polyUb-PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K alpha [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - DAP12 interactions (Canis familiaris)
    - DAP12 signaling (Canis familiaris)
      - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
      - PI3K associates with phosphorylated GAB2 (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
    - Role of phospholipids in phagocytosis (Canis familiaris)
      - PI3K binds to p-6Y-SYK (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
      - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)
        
        PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        PI3K [cytosol] (Canis familiaris)
        
        PI3K-catalytic subunit [cytosol] (Canis familiaris)
        
        PIK3CA [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A5F4C2B1

Gene Names

PIK3CA

Reference Genes

BioGPS Gene:488084 PIK3CA

ENSEMBL:ENSCAFG00845015587.1

Monarch:488084 PIK3CA

NCBI Gene:488084 PIK3CA

UCSC:A0A5F4C2B1 PIK3CA

Reference Transcript

RefSeq:XM_545208.5 PIK3CA

Other Identifiers

488084

CfaAffx.17516.1.S1_s_at

Participates

as an input of

as a component of

as a member of

PI3K-catalytic subunit [cytosol] (Canis familiaris)

Inferred From

PIK3CA [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_545208.2

ENSEMBL

ENSCAFT00845027831, ENSCAFP00845021905

VGNC

44555

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