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About
What is Reactome ?
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PIK3CA [cytosol]
Stable Identifier
R-CFA-74787
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
PIK3CA, A0A5F4C2B1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
RET signaling (Canis familiaris)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
Tie2 Signaling (Canis familiaris)
Interaction of Tie2 and p85 of PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p85 bound to Tie2 [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI3K alpha, beta, gamma [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K binds CD28 (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K binds ICOS (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K bound to TRAT [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Recruitment of PI3K to plasma membrane (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K bound to TRAT [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-2 family signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Regulation of signaling by CBL (Canis familiaris)
CBL ubiquitinates PI3K (Canis familiaris)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
K63polyUb-PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p85 regulatory unit of PI3K binds p-6Y-SYK (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
PI3K associates with phosphorylated GAB2 (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K binds to p-6Y-SYK (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PIK3C(1) [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R2 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R3 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)
PIK3(2) [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R2 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R3 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K bound to TRAT [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K bound to TRAT [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
RAC1,RAC2,RHOG activate PI3K (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS:GTP binds PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p21 RAS:GTP:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K bound to EPOR [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (q) signalling events (Canis familiaris)
G alpha (q) inhibits PI3K alpha (Canis familiaris)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
PI3K binds membrane-associated estrogen receptors (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PTK2 is recruited to methylated ESR1 (Canis familiaris)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Canis familiaris)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
Active ALK recruits PI3K (Canis familiaris)
Active ALK:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
Active ALK:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by EGFR (Canis familiaris)
GAB1 signalosome (Canis familiaris)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Canis familiaris)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by ERBB4 (Canis familiaris)
PI3K events in ERBB4 signaling (Canis familiaris)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
PI-3K cascade:FGFR1 (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
PI-3K cascade:FGFR2 (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
PI-3K cascade:FGFR3 (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
PI-3K cascade:FGFR4 (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
Activated FGFR bound to PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by MET (Canis familiaris)
MET activates PI3K/AKT signaling (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
PI3-kinase binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by SCF-KIT (Canis familiaris)
Direct recruitment of PI3K to p-KIT (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
Activated FGFR bound to PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
p-AXL binds PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-catalytic subunit [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 binds effectors at the plasma membrane (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
RAC1:GTP:RAC1 effectors [plasma membrane] (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
RAC2 GTPase cycle (Canis familiaris)
RAC2 binds effectors at the plasma membrane (Canis familiaris)
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Canis familiaris)
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A5F4C2B1
Gene Names
PIK3CA
Reference Genes
BioGPS Gene:488084 PIK3CA
ENSEMBL:ENSCAFG00845015587.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845015587.1 PIK3CA
Monarch:488084 PIK3CA
NCBI Gene:488084 PIK3CA
Reference Transcript
RefSeq:XM_545208.5 PIK3CA
Other Identifiers
488084
CfaAffx.17516.1.S1_s_at
GO:0003824
GO:0006629
GO:0014065
GO:0016301
GO:0016740
GO:0023052
GO:0035004
GO:0046854
GO:0048015
Participates
as an input of
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
as a component of
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Canis familiaris)
K63polyUb-PI3K alpha [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R3 [cytosol] (Canis familiaris)
PIK3CA:PIK3R2 [cytosol] (Canis familiaris)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
as a member of
PI3K-catalytic subunit [cytosol] (Canis familiaris)
Inferred From
PIK3CA [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_545208.2
OpenTargets
ENSG00000121879
Ensembl
ENSCAFG00845015587
,
ENSCAFT00845027831
,
ENSCAFP00845021905
VGNC
44555
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