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CYLD [cytosol]
Stable Identifier
R-CFA-741420
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
CYLD, A0A8I3MSL4
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Canis familiaris)
NOD1/2 Signaling Pathway (Canis familiaris)
CYLD deubiquitinates NEMO (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)
RIPK1 deubiquitinases [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
MIB2 binds CYLD (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
MIB2:CYLD:UBE2D2 [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
MIB2 ubiquitinates CYLD at K338, K530 (Canis familiaris)
MIB2:CYLD:UBE2D2 [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
RIPK1 deubiquitinases [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)
RIPK1 deubiquitinases [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
TNFR1-induced proapoptotic signaling (Canis familiaris)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MSL4
Gene Names
CYLD
Reference Genes
BioGPS Gene:611649 CYLD
ENSEMBL:ENSCAFG00845003806.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845003806.1 CYLD
KEGG Gene (Canis lupus familiaris):611649 CYLD
Monarch:611649 CYLD
NCBI Gene:611649 CYLD
Reference Transcript
RefSeq:XM_849343.4 CYLD
RefSeq:XM_005617567.2 CYLD
Other Identifiers
611649
CfaAffx.15385.1.S1_s_at
GO:0000278
GO:0002376
GO:0003824
GO:0004843
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005881
GO:0005886
GO:0005929
GO:0006954
GO:0007010
GO:0007155
GO:0007346
GO:0008270
GO:0009898
GO:0010803
GO:0012501
GO:0016020
GO:0016055
GO:0016579
GO:0016787
GO:0019901
GO:0023052
GO:0030154
GO:0030496
GO:0036064
GO:0036211
GO:0042995
GO:0043226
GO:0043369
GO:0044782
GO:0045087
GO:0045577
GO:0045582
GO:0046329
GO:0048471
GO:0048856
GO:0048872
GO:0050727
GO:0050728
GO:0050862
GO:0060544
GO:0061578
GO:0065003
GO:0070064
GO:0070266
GO:0070507
GO:0090090
GO:0097542
GO:0098542
GO:0140096
GO:1901026
GO:1901223
GO:1902017
GO:1903753
GO:1903829
GO:1990380
GO:2000493
GO:2001238
GO:2001242
Participates
as a component of
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Canis familiaris)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
MIB2:CYLD:UBE2D2 [cytosol] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
as an input of
OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)
CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)
MIB2 binds CYLD (Canis familiaris)
as a member of
RIPK1 deubiquitinases [cytosol] (Canis familiaris)
Other forms of this molecule
CYLD [cytosol]
phospho-CYLD [cytosol]
Inferred From
CYLD [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005617624.1
,
XP_854436.1
OpenTargets
ENSG00000083799
Ensembl
ENSCAFG00845003806
,
ENSCAFP00845005437
,
ENSCAFT00845006826
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