Reactome | LOC100687749 [cytosol]

LOC100687749 [cytosol]

Stable Identifier

R-CFA-72472

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RPL39, J9NZS7

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL39,RPL39L [cytosol] (Canis familiaris)
        
        LOC100687749 [cytosol] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL39,RPL39L [cytosol] (Canis familiaris)
        
        LOC100687749 [cytosol] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL39,RPL39L [cytosol] (Canis familiaris)
        
        LOC100687749 [cytosol] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL39,RPL39L [cytosol] (Canis familiaris)
        
        LOC100687749 [cytosol] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL39,RPL39L [cytosol] (Canis familiaris)
        
        LOC100687749 [cytosol] (Canis familiaris)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL39,RPL39L [cytosol] (Canis familiaris)
        
        LOC100687749 [cytosol] (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL39,RPL39L [cytosol] (Canis familiaris)
        
        LOC100687749 [cytosol] (Canis familiaris)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL39,RPL39L [cytosol] (Canis familiaris)
        
        LOC100687749 [cytosol] (Canis familiaris)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL39,RPL39L [cytosol] (Canis familiaris)
        
        LOC100687749 [cytosol] (Canis familiaris)
- rRNA processing (Canis familiaris)
  - rRNA processing in the nucleus and cytosol (Canis familiaris)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Canis familiaris)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL39,RPL39L [cytosol] (Canis familiaris)
        
        LOC100687749 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:J9NZS7

Gene Names

LOC100687749

Reference Genes

BioGPS Gene:100682542 LOC100687749

BioGPS Gene:100685611 LOC100687749

BioGPS Gene:100685924 LOC100687749

BioGPS Gene:100686103 LOC100687749

BioGPS Gene:100687285 LOC100687749

BioGPS Gene:100687749 LOC100687749

ENSEMBL:ENSCAFG00845002692.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845002692.1 LOC100687749

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845005461.1 LOC100687749

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845017474.1 LOC100687749

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845019073.1 LOC100687749

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845025157.1 LOC100687749

KEGG Gene (Canis lupus familiaris):100682542 LOC100687749

KEGG Gene (Canis lupus familiaris):100685611 LOC100687749

KEGG Gene (Canis lupus familiaris):100685924 LOC100687749

KEGG Gene (Canis lupus familiaris):100686103 LOC100687749

KEGG Gene (Canis lupus familiaris):100687285 LOC100687749

KEGG Gene (Canis lupus familiaris):100687749 LOC100687749

Monarch:100682542 LOC100687749

Monarch:100685611 LOC100687749

Monarch:100685924 LOC100687749

Monarch:100686103 LOC100687749

Monarch:100687285 LOC100687749

Monarch:100687749 LOC100687749

NCBI Gene:100682542 LOC100687749

NCBI Gene:100685611 LOC100687749

NCBI Gene:100685924 LOC100687749

NCBI Gene:100686103 LOC100687749

NCBI Gene:100687285 LOC100687749

NCBI Gene:100687749 LOC100687749

Reference Transcript

Other Identifiers

100682542

100685611

100685924

100686103

100687285

100687749

119870509

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0043226

Participates

as a member of

RPL39,RPL39L [cytosol] (Canis familiaris)

Inferred From

RPL39 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005619861.1, XP_005626145.1, XP_005640037.1, XP_005623370.1, XP_003434034.1, XP_005641800.1

Ensembl

ENSCAFG00845019073, ENSCAFP00845034780, ENSCAFT00845033655, ENSCAFG00845017474, ENSCAFG00845002692, ENSCAFP00845003822, ENSCAFP00845024246, ENSCAFP00845026348, ENSCAFG00845025157, ENSCAFT00845030939, ENSCAFG00845005461, ENSCAFT00845004777, ENSCAFP00845007603, ENSCAFT00845044384, ENSCAFT00845009723

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