Reactome | TMED3 [transport vesicle]

TMED3 [transport vesicle]

Stable Identifier

R-CFA-6808874

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

transport vesicle

Synonyms

TMED3, J9P479

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Asparagine N-linked glycosylation (Canis familiaris)
    - Transport to the Golgi and subsequent modification (Canis familiaris)
      - ER to Golgi Anterograde Transport (Canis familiaris)
        
        COPI-mediated anterograde transport (Canis familiaris)
        
        ARFGAPs stimulate ARF GTPase activity (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - ER to Golgi Anterograde Transport (Canis familiaris)
    - COPI-mediated anterograde transport (Canis familiaris)
      - ARFGAPs stimulate ARF GTPase activity (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Canis familiaris)
    - Golgi-to-ER retrograde transport (Canis familiaris)
      - COPI-dependent Golgi-to-ER retrograde traffic (Canis familiaris)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Canis familiaris)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Canis familiaris)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Canis familiaris)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Canis familiaris)
        
        p24 dimers [transport vesicle] (Canis familiaris)
        
        TMED3 dimer [transport vesicle] (Canis familiaris)
        
        TMED3 [transport vesicle] (Canis familiaris)

External Reference Information

External Reference

UniProt:J9P479

Gene Names

TMED3

Reference Genes

BioGPS Gene:100685718 TMED3

ENSEMBL:ENSCAFG00000031547

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000031547 TMED3

KEGG Gene (Canis lupus familiaris):100685718 TMED3

Monarch:100685718 TMED3

NCBI Gene:100685718 TMED3

Reference Transcript

RefSeq:XM_005618431.1 TMED3

Other Identifiers

100685718

CfaAffx.21593.1.S1_at

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0006810

GO:0006886

GO:0006888

GO:0007030

GO:0008150

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0030126

GO:0030134

GO:0031410

GO:0032991

GO:0033116

GO:0043226

Participant Of

hasComponent

TMED3 dimer [transport vesicle]

Other forms of this molecule

TMED3 [endoplasmic reticulum membrane]

TMED3 [endoplasmic reticulum-Golgi intermediate compartment membrane]

TMED3 [Golgi membrane]

Inferred From

TMED3 [transport vesicle] (Homo sapiens)

Cross References

RefSeq

XP_005618488.1

OpenTargets

ENSG00000166557

Ensembl

ENSCAFT00000046175, ENSCAFG00000031547, ENSCAFP00000040358

VGNC

47438

Cite Us!