Reactome | ICE2 [nucleoplasm]

ICE2 [nucleoplasm]

Stable Identifier

R-CFA-6807421

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

ICE2, J9NVQ1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - RNA polymerase II transcribes snRNA genes (Canis familiaris)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE2 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE2 [nucleoplasm] (Canis familiaris)
    - Integrator complex processes the 3' end of snRNA (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE2 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE2 [nucleoplasm] (Canis familiaris)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE2 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE2 [nucleoplasm] (Canis familiaris)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Canis familiaris)
      - LEC [nucleoplasm] (Canis familiaris)
        
        ICE2 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE2 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:J9NVQ1

Gene Names

ICE2

Reference Genes

ENSEMBL:ENSCAFG00000016690

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000016690 ICE2

Other Identifiers

608993

CfaAffx.25528.1.S1_at

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0008023

GO:0008150

GO:0009058

GO:0032991

GO:0034641

GO:0042795

GO:0042796

GO:0043226

GO:0045945

Participant Of

hasComponent

LEC [nucleoplasm]

Inferred From

ICE2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000128915

Ensembl

ENSCAFP00000037243, ENSCAFG00000016690, ENSCAFT00000046765

VGNC

41859

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