Reactome | FAS [plasma membrane]

FAS [plasma membrane]

Stable Identifier

R-CFA-66248

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

FAS, F1P7R0

Locations in the PathwayBrowser

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Programmed Cell Death (Canis familiaris)

- Apoptosis (Canis familiaris)
  - Caspase activation via extrinsic apoptotic signalling pathway (Canis familiaris)
    - Caspase activation via Death Receptors in the presence of ligand (Canis familiaris)
      - Dimerization of procaspase-8 (Canis familiaris)
        
        FAS-mediated dimerization of procaspase-8 (Canis familiaris)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
      - Regulation by c-FLIP (Canis familiaris)
        
        FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1P7R0

Gene Names

FAS

Reference Genes

ENSEMBL:ENSCAFG00000015712

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000015712 FAS

Participates

as an input of

FASL binds FAS Receptor (Canis familiaris)

as a component of

FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)

Inferred From

FAS [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000026103

VGNC

40734