Reactome | FAS [plasma membrane]

FAS [plasma membrane]

Stable Identifier

R-CFA-66248

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

F1P7Q7

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Canis familiaris)

- Apoptosis (Canis familiaris)
  - Caspase activation via extrinsic apoptotic signalling pathway (Canis familiaris)
    - Caspase activation via Death Receptors in the presence of ligand (Canis familiaris)
      - Dimerization of procaspase-8 (Canis familiaris)
        
        FAS-mediated dimerization of procaspase-8 (Canis familiaris)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
      - Regulation by c-FLIP (Canis familiaris)
        
        Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Canis familiaris)
        
        DISC [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
        
        DISC:procaspase-8 [plasma membrane] (Canis familiaris)
        
        DISC [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
        
        FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
- Regulated Necrosis (Canis familiaris)
  - RIPK1-mediated regulated necrosis (Canis familiaris)
    - RIPK3 binds RIPK1 (Canis familiaris)
      - DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
        
        DISC:procaspase-8 [plasma membrane] (Canis familiaris)
        
        DISC [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
      - DISC:procaspase-8:FLIP(S) [plasma membrane] (Canis familiaris)
        
        DISC:procaspase-8 [plasma membrane] (Canis familiaris)
        
        DISC [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
    - Regulation of necroptotic cell death (Canis familiaris)
      - CASP8 activity is inhibited (Canis familiaris)
        
        FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)
        
        DISC:procaspase-8 [plasma membrane] (Canis familiaris)
        
        DISC [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
        
        DISC:procaspase-8 [plasma membrane] (Canis familiaris)
        
        DISC [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
        
        FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)
        
        DISC:procaspase-8 [plasma membrane] (Canis familiaris)
        
        DISC [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Canis familiaris)
        
        DISC:procaspase-8 [plasma membrane] (Canis familiaris)
        
        DISC [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Canis familiaris)
        
        FASL:FAS Receptor monomer [plasma membrane] (Canis familiaris)
        
        FAS [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1P7Q7

Reference Genes

BioGPS Gene:486469

dbSNP Gene:486469

ENSEMBL:ENSCAFG00000015712

KEGG Gene (Canis familiaris):486469

Monarch:486469

NCBI Gene:486469

Reference Transcript

RefSeq:XM_005636650.1

Other Identifiers

486469

AAEX03014955

Cfa.18344.1.S1_s_at

ENSCAFG00000015712

ENSCAFP00000023094

ENSCAFT00000024890

EntrezGene:486469

F1P7R0

FAS

FAS-201

GO:0002376

GO:0003674

GO:0004888

GO:0005515

GO:0005575

GO:0006915

GO:0006955

GO:0007165

GO:0008219

GO:0016020

GO:0016021

IPR000488

IPR001368

IPR008063

IPR011029

IPR033998

IPR033999

PF00020

PF00531

PR01680

SM00005

SM00208

UPI0002749F1D

VGNC:40734

XM_005636650

XM_022410445

XP_005636707

XP_022266153

Participant Of

input

FASL binds FAS Receptor

hasComponent

FASL:FAS Receptor monomer [plasma membrane]

Inferred From

FAS [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005636707.1