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LYPLA1 [nucleoplasm]
Stable Identifier
R-CFA-65748
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
TCEA1, A0A8I3S9G1
Locations in the PathwayBrowser
Expand all
DNA Repair (Canis familiaris)
Nucleotide Excision Repair (Canis familiaris)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
Dual incision in TC-NER (Canis familiaris)
3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)
TC-NER incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)
TC-NER incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
ERCC5 and RPA bind TC-NER site (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Formation of TC-NER Pre-Incision Complex (Canis familiaris)
Assembly of the pre-incision complex in TC-NER (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Gap-filling DNA repair synthesis and ligation in TC-NER (Canis familiaris)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Transcription of DNA Repair Genes (Canis familiaris)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Canis familiaris)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Canis familiaris)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Canis familiaris)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Canis familiaris)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Canis familiaris)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
RNA Polymerase II Pre-transcription Events (Canis familiaris)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Canis familiaris)
Paused processive elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Processive elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Canis familiaris)
Processive elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Abortive termination of elongation after arrest (Canis familiaris)
Aborted elongation complex after arrest [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Processive elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Elongating transcript encounters a lesion in the template (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Processive elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Resumption of elongation after recovery from pausing (Canis familiaris)
Paused processive elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Processive elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
TFIIS-mediated recovery of elongation from arrest (Canis familiaris)
Processive elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
RNA Polymerase II Transcription Elongation (Canis familiaris)
Addition of nucleotides leads to transcript elongation (Canis familiaris)
Elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Processive elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Formation of RNA Pol II elongation complex (Canis familiaris)
Recruitment of elongation factors to form elongation complex (Canis familiaris)
Elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Pol II elongation complex moves on the template as transcript elongates (Canis familiaris)
Elongation complex prior to separation [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Processive elongation complex [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Separation of elongating transcript from template (Canis familiaris)
Elongation complex prior to separation [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Canis familiaris)
LYPLA1 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3S9G1
Gene Names
LYPLA1
Reference Genes
ENSEMBL:ENSCAFG00845025526.1
UCSC:A0A8I3S9G1 LYPLA1
Other Identifiers
477879
Cfa.11050.1.S1_s_at
Cfa.18722.1.S1_s_at
CfaAffx.11343.1.S1_at
GO:0003676
GO:0003677
GO:0003824
GO:0005634
GO:0005737
GO:0005783
GO:0005886
GO:0006351
GO:0006355
GO:0006368
GO:0008270
GO:0016020
GO:0016787
GO:0031965
GO:0043226
GO:0045944
GO:0046872
Participates
as an output of
Elongating transcript encounters a lesion in the template (Canis familiaris)
as a component of
Aborted elongation complex after arrest [nucleoplasm] (Canis familiaris)
Paused processive elongation complex [nucleoplasm] (Canis familiaris)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Canis familiaris)
Elongation complex prior to separation [nucleoplasm] (Canis familiaris)
Processive elongation complex [nucleoplasm] (Canis familiaris)
Elongation complex [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Canis familiaris)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Canis familiaris)
as an input of
Recruitment of elongation factors to form elongation complex (Canis familiaris)
Assembly of the pre-incision complex in TC-NER (Canis familiaris)
Inferred From
TCEA1 [nucleoplasm]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFT00845045081
,
ENSCAFP00845035342
,
ENSCAFG00845025526
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