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CASP8 [cytosol]
Stable Identifier
R-CFA-57031
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
CASP8(1-479), Q38JA9
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Canis familiaris)
NOD1/2 Signaling Pathway (Canis familiaris)
NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Canis familiaris)
Long prodomain caspases [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
NOD1:iE-DAP:Long prodomain caspases [cytosol] (Canis familiaris)
Long prodomain caspases [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
TRIF-mediated programmed cell death (Canis familiaris)
Caspase-8 processing within TLR4 complex (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Caspase activation via extrinsic apoptotic signalling pathway (Canis familiaris)
Caspase activation via Death Receptors in the presence of ligand (Canis familiaris)
Caspase-8 processing within TLR4 complex (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Dimerization of procaspase-8 (Canis familiaris)
FAS-mediated dimerization of procaspase-8 (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Canis familiaris)
procaspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
TNF-mediated dimerization of procaspase-8 (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Canis familiaris)
procaspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Regulation by c-FLIP (Canis familiaris)
Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Canis familiaris)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
Regulation of necroptotic cell death (Canis familiaris)
CASP8 activity is inhibited (Canis familiaris)
FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
OPTN binds CASP8 (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
OPTN:CASP8 [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:Q38JA9
Gene Names
CASP8
Reference Genes
BioGPS Gene:488473 CASP8
ENSEMBL:ENSCAFG00845030024.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845030024.1 CASP8
KEGG Gene (Canis lupus familiaris):488473 CASP8
Monarch:488473 CASP8
NCBI Gene:488473 CASP8
Reference Transcript
RefSeq:XM_005640424.2 CASP8
RefSeq:XM_005640426.2 CASP8
RefSeq:XM_005640427.1 CASP8
RefSeq:XM_005640423.1 CASP8
RefSeq:XM_005640425.1 CASP8
RefSeq:NM_001048029.1 CASP8
Other Identifiers
488473
Cfa.1722.1.S1_at
CfaAffx.18878.1.S1_s_at
GO:0002376
GO:0003824
GO:0004197
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006915
GO:0008233
GO:0008234
GO:0012501
GO:0016787
GO:0023052
GO:0030154
GO:0030163
GO:0031264
GO:0031265
GO:0031625
GO:0032731
GO:0032991
GO:0034612
GO:0035877
GO:0036462
GO:0042802
GO:0042981
GO:0043123
GO:0043124
GO:0043226
GO:0045651
GO:0045862
GO:0048856
GO:0051603
GO:0051604
GO:0060546
GO:0071260
GO:0097110
GO:0097153
GO:0097190
GO:0097191
GO:0097194
GO:0097199
GO:0097342
GO:0140096
Participates
as an input of
OPTN binds CASP8 (Canis familiaris)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)
FAS-mediated dimerization of procaspase-8 (Canis familiaris)
TNF-mediated dimerization of procaspase-8 (Canis familiaris)
as a component of
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Canis familiaris)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Canis familiaris)
OPTN:CASP8 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Canis familiaris)
procaspase-8 dimer [cytosol] (Canis familiaris)
as a member of
Long prodomain caspases [cytosol] (Canis familiaris)
Other forms of this molecule
CASP8 [cytosol]
CASP8 [mitochondrial outer membrane]
CASP8 [mitochondrial outer membrane]
CASP8 [cytosol]
CASP8 [cytosol]
Inferred From
CASP8(1-479) [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005640482.1
,
XP_005640484.1
,
XP_005640480.1
,
XP_005640483.1
,
NP_001041494.1
,
XP_005640481.1
OpenTargets
ENSG00000064012
Ensembl
ENSCAFT00845053200
,
ENSCAFG00845030024
,
ENSCAFP00845041772
VGNC
38736
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