Reactome | CTSC [COPII-coated ER to Golgi transport vesicle]

CTSC [COPII-coated ER to Golgi transport vesicle]

Stable Identifier

R-CFA-5689724

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

COPII-coated ER to Golgi transport vesicle

Synonyms

(Glc)3(GlcNAc)2(Man)9-CTSC, A0A8I3S5V2

Locations in the PathwayBrowser

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Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Asparagine N-linked glycosylation (Canis familiaris)
    - Transport to the Golgi and subsequent modification (Canis familiaris)
      - ER to Golgi Anterograde Transport (Canis familiaris)
        
        COPII-mediated vesicle transport (Canis familiaris)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CSNK1D phosphorylates SEC23 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        Nucleotide exchange on RAB1 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        Vesicle budding (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - ER to Golgi Anterograde Transport (Canis familiaris)
    - COPII-mediated vesicle transport (Canis familiaris)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
      - COPII coat binds TRAPPCII and RAB1:GDP (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
      - CSNK1D phosphorylates SEC23 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
      - Nucleotide exchange on RAB1 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
      - Vesicle budding (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S5V2

Gene Names

CTSC

Reference Genes

ENSEMBL:ENSCAFG00845026305.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026305.1 CTSC

Other Identifiers

403458

CfaAffx.14173.1.S1_s_at

GO:0003824

GO:0005764

GO:0005773

GO:0006508

GO:0008233

GO:0008234

GO:0016787

GO:0043226

GO:0140096

Participates

as a member of

glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)

Other forms of this molecule

CTSC [lysosomal lumen]

CTSC [extracellular region]

CTSC [azurophil granule lumen]

CTSC [endoplasmic reticulum-Golgi intermediate compartment membrane]

CTSC [endoplasmic reticulum lumen]

Inferred From

(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position

Modification

N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Cross References

OpenTargets

ENSG00000109861

Ensembl

ENSCAFT00845046453, ENSCAFP00845036469, ENSCAFG00845026305

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