Reactome | CTSC [endoplasmic reticulum lumen]

CTSC [endoplasmic reticulum lumen]

Stable Identifier

R-CFA-5689430

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

endoplasmic reticulum lumen

Synonyms

(Glc)3(GlcNAc)2(Man)9-CTSC, A0A8I3S5V2

Locations in the PathwayBrowser

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Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Asparagine N-linked glycosylation (Canis familiaris)
    - Transport to the Golgi and subsequent modification (Canis familiaris)
      - ER to Golgi Anterograde Transport (Canis familiaris)
        
        COPII-mediated vesicle transport (Canis familiaris)
        
        Inner coat assembly and cargo binding (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        Loss of SAR1B GTPase (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        SEC31:SEC13 and v-SNARE recruitment (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        Vesicle budding (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        Cargo concentration in the ER (Canis familiaris)
        
        Inner coat assembly and cargo binding (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        LMAN family proteins bind glycosylated cargo (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - ER to Golgi Anterograde Transport (Canis familiaris)
    - COPII-mediated vesicle transport (Canis familiaris)
      - Inner coat assembly and cargo binding (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
      - Loss of SAR1B GTPase (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
      - SEC31:SEC13 and v-SNARE recruitment (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
      - Vesicle budding (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
    - Cargo concentration in the ER (Canis familiaris)
      - Inner coat assembly and cargo binding (Canis familiaris)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
      - LMAN family proteins bind glycosylated cargo (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)
        
        CTSC [endoplasmic reticulum lumen] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S5V2

Gene Names

CTSC

Reference Genes

ENSEMBL:ENSCAFG00845026305.1

UCSC:A0A8I3S5V2 CTSC

Other Identifiers

403458

CfaAffx.14173.1.S1_s_at

GO:0003824

GO:0005764

GO:0005773

GO:0006508

GO:0008234

GO:0016787

GO:0043226

GO:0140096

Participates

as a member of

glycosylated LMAN cargo [endoplasmic reticulum lumen] (Canis familiaris)

Other forms of this molecule

CTSC [lysosomal lumen]

CTSC [endoplasmic reticulum-Golgi intermediate compartment membrane]

CTSC [COPII-coated ER to Golgi transport vesicle]

CTSC [extracellular region]

CTSC [azurophil granule lumen]

Inferred From

(Glc)3(GlcNAc)2(Man)9-CTSC [endoplasmic reticulum lumen] (Homo sapiens)

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position

Modification

N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Cross References

ENSEMBL

ENSCAFP00845036469, ENSCAFG00845026305, ENSCAFT00845046453

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