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phospho-CHEK2 [nucleoplasm]
Stable Identifier
R-CFA-5683784
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
p-S,3T-CHEK2, A0A8I3QAH4
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Canis familiaris)
p53-Dependent G1/S DNA damage checkpoint (Canis familiaris)
p53-Dependent G1 DNA Damage Response (Canis familiaris)
Stabilization of p53 (Canis familiaris)
CHEK2 phosphorylates TP53 (Canis familiaris)
phospho-CHEK2 [nucleoplasm] (Canis familiaris)
Phosphorylation of MDM4 by CHEK2 (Canis familiaris)
phospho-CHEK2 [nucleoplasm] (Canis familiaris)
p53-Independent G1/S DNA damage checkpoint (Canis familiaris)
p53-Independent DNA Damage Response (Canis familiaris)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Canis familiaris)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Canis familiaris)
phospho-CHEK2 [nucleoplasm] (Canis familiaris)
G2/M Checkpoints (Canis familiaris)
G2/M DNA damage checkpoint (Canis familiaris)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Canis familiaris)
Phosphorylation of Cdc25C at Ser216 by CHEK2 (Canis familiaris)
phospho-CHEK2 [nucleoplasm] (Canis familiaris)
p-T68-CHEK2 autophosphorylates (Canis familiaris)
phospho-CHEK2 [nucleoplasm] (Canis familiaris)
DNA Repair (Canis familiaris)
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
CHEK2 phosphorylates BRCA1 (Canis familiaris)
phospho-CHEK2 [nucleoplasm] (Canis familiaris)
p-T68-CHEK2 autophosphorylates (Canis familiaris)
phospho-CHEK2 [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Activity through Methylation (Canis familiaris)
CHEK2 phosphorylates TTC5 (Canis familiaris)
phospho-CHEK2 [nucleoplasm] (Canis familiaris)
Regulation of TP53 Activity through Phosphorylation (Canis familiaris)
CHEK2 phosphorylates TP53 (Canis familiaris)
phospho-CHEK2 [nucleoplasm] (Canis familiaris)
Regulation of TP53 Expression and Degradation (Canis familiaris)
Regulation of TP53 Degradation (Canis familiaris)
Phosphorylation of MDM4 by CHEK2 (Canis familiaris)
phospho-CHEK2 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3QAH4
Gene Names
CHEK2
Reference Genes
ENSEMBL:ENSCAFG00845030072.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845030072.1 CHEK2
Reference Transcript
RefSeq:XM_005636390.2 CHEK2
Other Identifiers
486338
Cfa.18010.1.S1_s_at
CfaAffx.18523.1.S1_s_at
GO:0000086
GO:0000278
GO:0000781
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005794
GO:0006281
GO:0006302
GO:0006351
GO:0006355
GO:0006468
GO:0006974
GO:0007010
GO:0007059
GO:0008630
GO:0012501
GO:0016605
GO:0016740
GO:0019901
GO:0023052
GO:0030163
GO:0031573
GO:0031625
GO:0036211
GO:0042176
GO:0042770
GO:0042802
GO:0042803
GO:0043226
GO:0045893
GO:0050821
GO:0090307
GO:0140014
GO:0140096
Participates
as an output of
p-T68-CHEK2 autophosphorylates (Canis familiaris)
Other forms of this molecule
phospho-CHEK2 [nucleoplasm]
CHEK2 [nucleoplasm]
Inferred From
p-S,3T-CHEK2 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 68 (in Homo sapiens)
Coordinate
68
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 379 (in Homo sapiens)
Coordinate
379
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 383 (in Homo sapiens)
Coordinate
383
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 387 (in Homo sapiens)
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_005636447.1
OpenTargets
ENSG00000183765
Ensembl
ENSCAFG00845030072
,
ENSCAFT00845053394
,
ENSCAFP00845041946
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