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TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
Stable Identifier
R-CFA-5668433
Type
Complex
Species
Canis familiaris
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane]
(Canis familiaris)
TRAF1:TRAF2:K63polyUb-cIAP1,2 [cytosol]
(Canis familiaris)
TRAF3:NIK [cytosol]
(Canis familiaris)
Participates
as an input of
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)
as an output of
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
This entity regulates
Negatively
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
(Canis familiaris)
Inferred From
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
(Homo sapiens)
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