Reactome | LTA [plasma membrane]

LTA [plasma membrane]

Stable Identifier

R-CFA-5667153

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

LTA, Q5WR07

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - TNFR2 non-canonical NF-kB pathway (Canis familiaris)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
    - Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Canis familiaris)
      - 2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
      - TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
    - TNFs bind their physiological receptors (Canis familiaris)
      - LTA trimer binds TNFRSF1A,1B,14 (Canis familiaris)
        
        LTA trimer [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA trimer:TNFRSF1A,1B,14 [plasma membrane] (Canis familiaris)
        
        LTA trimer [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Canis familiaris)
        
        lymphotoxin (LA) [plasma membrane] (Canis familiaris)
        
        LTA1B2 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)
        
        LTA2B1 [plasma membrane] (Canis familiaris)
        
        LTA [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:Q5WR07

Gene Names

LTA

Reference Genes

BioGPS Gene:607183 LTA

ENSEMBL:ENSCAFG00845010521

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000000515.3 LTA

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030005134.1 LTA

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040009649.1 LTA

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805014243 LTA

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845010521.1 LTA

KEGG Gene (Canis lupus familiaris):607183 LTA

Monarch:607183 LTA

NCBI Gene:607183 LTA

Reference Transcript

Other Identifiers

607183

CfaAffx.1716.1.S1_at

GO:0002376

GO:0002876

GO:0002925

GO:0005164

GO:0005515

GO:0006954

GO:0006955

GO:0006959

GO:0016020

GO:0032729

GO:0048535

GO:0048856

GO:0050830

GO:0098542

Participates

as a component of

Inferred From

LTA [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001300778.1, XP_848886.2

OpenTargets

ENSG00000226979

Ensembl

ENSCAFP00845014444, ENSCAFG00845010521, ENSCAFT00845018517

VGNC

42852

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