Reactome | ERCC6 [nucleoplasm]

ERCC6 [nucleoplasm]

Stable Identifier

R-CFA-54429

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

ERCC6, E2QSK6

Locations in the PathwayBrowser

Expand all

DNA Repair (Canis familiaris)

- Nucleotide Excision Repair (Canis familiaris)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
    - Dual incision in TC-NER (Canis familiaris)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)
        
        TC-NER incision complex [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)
        
        TC-NER incision complex [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
        
        TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
    - Formation of TC-NER Pre-Incision Complex (Canis familiaris)
      - ERCC6 binds stalled RNA Pol II (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
      - ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
      - UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
        
        TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Canis familiaris)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        ERCC6 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2QSK6

Gene Names

ERCC6

Reference Genes

BioGPS Gene:477747 ERCC6

ENSEMBL:ENSCAFG00000006624

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000006624 ERCC6

Monarch:477747 ERCC6

NCBI Gene:477747 ERCC6

Reference Transcript

RefSeq:XM_534944.4 ERCC6

Other Identifiers

477747

Cfa.1909.1.A1_s_at

CfaAffx.10874.1.S1_at

GO:0000012

GO:0000077

GO:0000166

GO:0000303

GO:0003674

GO:0003677

GO:0003682

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006259

GO:0006281

GO:0006283

GO:0006284

GO:0006290

GO:0006362

GO:0006464

GO:0006950

GO:0006974

GO:0006979

GO:0007049

GO:0007165

GO:0007256

GO:0007257

GO:0008022

GO:0008023

GO:0008094

GO:0008150

GO:0008219

GO:0008630

GO:0009058

GO:0009411

GO:0009636

GO:0010165

GO:0010224

GO:0010332

GO:0016887

GO:0022008

GO:0030154

GO:0030182

GO:0030234

GO:0030296

GO:0031175

GO:0032784

GO:0032786

GO:0032991

GO:0034641

GO:0035264

GO:0040007

GO:0042592

GO:0043044

GO:0043167

GO:0043226

GO:0044877

GO:0045494

GO:0045739

GO:0047485

GO:0048856

GO:0051276

GO:0060261

GO:0061098

GO:0090734

GO:0097680

GO:1905168

GO:2001033

Participant Of

hasComponent

input

ERCC6 binds stalled RNA Pol II

Other forms of this molecule

ERCC6 [nucleoplasm]

Inferred From

ERCC6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_534944.2

OpenTargets

ENSG00000225830

Ensembl

ENSCAFT00000010674, ENSCAFP00000009895, ENSCAFG00000006624

VGNC

40445

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