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POLB [nucleoplasm]
Stable Identifier
R-CFA-53845
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
POLB, A0A8I3NDB6
Locations in the PathwayBrowser
Expand all
DNA Repair (Canis familiaris)
Base Excision Repair (Canis familiaris)
Resolution of Abasic Sites (AP sites) (Canis familiaris)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Canis familiaris)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Canis familiaris)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Canis familiaris)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2 recruits POLB to incised AP site (Canis familiaris)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Canis familiaris)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Canis familiaris)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Canis familiaris)
PCNA-Dependent Long Patch Base Excision Repair (Canis familiaris)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Canis familiaris)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB-Dependent Long Patch Base Excision Repair (Canis familiaris)
LIG1 binds POLB at long-patch BER site (Canis familiaris)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
LIG1 bound to POLB ligates SSB (Canis familiaris)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
LIG1:POLB:dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Canis familiaris)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Canis familiaris)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Canis familiaris)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB-mediated DNA strand displacement synthesis (Canis familiaris)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
Recruitment of POLB to oxidatively damaged AP site (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
Resolution of AP sites via the single-nucleotide replacement pathway (Canis familiaris)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Canis familiaris)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB:SSB-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
Recruitment of POLB to the AP site (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Canis familiaris)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Canis familiaris)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB:SSB-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB:SSB-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
Resynthesis of excised residue by POLB (Canis familiaris)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB:SSB-gap-dsDNA [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
USP47 deubiquitinates POLB (Canis familiaris)
USP47:POLB [nucleoplasm] (Canis familiaris)
POLB [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NDB6
Gene Names
POLB
Reference Genes
BioGPS Gene:494001 POLB
ENSEMBL:ENSCAFG00845006104.1
Monarch:494001 POLB
NCBI Gene:494001 POLB
UCSC:A0A8I3NDB6 POLB
Reference Transcript
RefSeq:XM_532790.5 POLB
Other Identifiers
494001
Cfa.2051.1.S1_s_at
GO:0001701
GO:0002376
GO:0003677
GO:0003824
GO:0003887
GO:0005634
GO:0005737
GO:0005874
GO:0005876
GO:0006259
GO:0006281
GO:0006284
GO:0006287
GO:0006303
GO:0006310
GO:0006915
GO:0006954
GO:0006974
GO:0007435
GO:0008017
GO:0008092
GO:0008630
GO:0012501
GO:0016445
GO:0016446
GO:0016740
GO:0016829
GO:0019899
GO:0032991
GO:0043226
GO:0046872
GO:0048535
GO:0048536
GO:0048856
GO:0048872
GO:0051402
GO:0051575
GO:0071707
GO:0071897
GO:0140078
GO:0140097
Participates
as a component of
USP47:POLB [nucleoplasm] (Canis familiaris)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Canis familiaris)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Canis familiaris)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB:SSB-gap-dsDNA [nucleoplasm] (Canis familiaris)
LIG1:POLB:dsDNA [nucleoplasm] (Canis familiaris)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Canis familiaris)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Canis familiaris)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Canis familiaris)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Canis familiaris)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Canis familiaris)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Canis familiaris)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Canis familiaris)
as an input of
Recruitment of POLB to the AP site (Canis familiaris)
Recruitment of POLB to oxidatively damaged AP site (Canis familiaris)
NEIL1,NEIL2 recruits POLB to incised AP site (Canis familiaris)
as an output of
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Canis familiaris)
Other forms of this molecule
POLB [nucleoplasm]
Inferred From
POLB [nucleoplasm]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845008457
,
ENSCAFT00845010836
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