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DERL2 [endoplasmic reticulum membrane]
Stable Identifier
R-CFA-5362350
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
endoplasmic reticulum membrane
Synonyms
DERL2, A0A8I3MFR7
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog ligand biogenesis (Canis familiaris)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Canis familiaris)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
DERL oligomer [endoplasmic reticulum membrane] (Canis familiaris)
DERLs [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
DERL oligomer [endoplasmic reticulum membrane] (Canis familiaris)
DERLs [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
DERL oligomer [endoplasmic reticulum membrane] (Canis familiaris)
DERLs [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
DERL oligomer [endoplasmic reticulum membrane] (Canis familiaris)
DERLs [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
DERL oligomer [endoplasmic reticulum membrane] (Canis familiaris)
DERLs [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
DERL oligomer [endoplasmic reticulum membrane] (Canis familiaris)
DERLs [endoplasmic reticulum membrane] (Canis familiaris)
DERL2 [endoplasmic reticulum membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MFR7
Gene Names
DERL2
Reference Genes
ENSEMBL:ENSCAFG00845002594.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845002594.1 DERL2
Other Identifiers
606991
Cfa.3368.1.S1_at
CfaAffx.23819.1.S1_at
GO:0001967
GO:0005047
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005789
GO:0006886
GO:0008284
GO:0023052
GO:0030163
GO:0030307
GO:0030433
GO:0030968
GO:0030970
GO:0031410
GO:0043226
GO:0044877
GO:1904153
Participates
as a component of
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
as a candidate of
DERLs [endoplasmic reticulum membrane] (Canis familiaris)
Inferred From
DERL2 [endoplasmic reticulum membrane]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000072849
Ensembl
ENSCAFP00845003693
,
ENSCAFG00845002594
,
ENSCAFT00845004621
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