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What is Reactome ?
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DDB1 [nucleoplasm]
Stable Identifier
R-CFA-53489
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
DDB1, A0A8I3NKI4
Locations in the PathwayBrowser
Expand all
DNA Repair (Canis familiaris)
DNA Damage Bypass (Canis familiaris)
Recognition of DNA damage by PCNA-containing replication complex (Canis familiaris)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Nucleotide Excision Repair (Canis familiaris)
Global Genome Nucleotide Excision Repair (GG-NER) (Canis familiaris)
DNA Damage Recognition in GG-NER (Canis familiaris)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
PARP1 or PARP2 binds DDB2 at GG-NER site (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
UV-DDB ubiquitinates XPC (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Canis familiaris)
UV-DDB:COP9 Signalosome [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Dual Incision in GG-NER (Canis familiaris)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Canis familiaris)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Canis familiaris)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Canis familiaris)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Formation of Incision Complex in GG-NER (Canis familiaris)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Canis familiaris)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Canis familiaris)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
CHD1L is recruited to GG-NER site (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Formation of the pre-incision complex in GG-NER (Canis familiaris)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
RNF111 ubiquitinates SUMOylated XPC (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Recruitment of XPA and release of CAK (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
TFIIH binds GG-NER site to form a verification complex (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
Dual incision in TC-NER (Canis familiaris)
3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)
TC-NER incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)
TC-NER incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
ERCC5 and RPA bind TC-NER site (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Formation of TC-NER Pre-Incision Complex (Canis familiaris)
Assembly of the pre-incision complex in TC-NER (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Gap-filling DNA repair synthesis and ligation in TC-NER (Canis familiaris)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Canis familiaris)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Canis familiaris)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Canis familiaris)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Canis familiaris)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Canis familiaris)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Canis familiaris)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Canis familiaris)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Canis familiaris)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
DDB1 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NKI4
Gene Names
DDB1
Reference Genes
BioGPS Gene:476067 DDB1
ENSEMBL:ENSCAFG00845012984.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845012984.1 DDB1
KEGG Gene (Canis lupus familiaris):476067 DDB1
Monarch:476067 DDB1
NCBI Gene:476067 DDB1
Reference Transcript
RefSeq:XM_533275.5 DDB1
Other Identifiers
476067
CfaAffx.24959.1.S1_s_at
CfaAffx.24971.1.S1_at
GO:0000278
GO:0003676
GO:0003677
GO:0003684
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005975
GO:0006281
GO:0006511
GO:0006915
GO:0006974
GO:0007010
GO:0007056
GO:0007059
GO:0010498
GO:0012501
GO:0016055
GO:0016567
GO:0019076
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030674
GO:0031464
GO:0031465
GO:0032991
GO:0035234
GO:0036211
GO:0042752
GO:0043066
GO:0043161
GO:0043226
GO:0044725
GO:0044877
GO:0045070
GO:0045722
GO:0045732
GO:0046726
GO:0048856
GO:0051093
GO:0051702
GO:0060090
GO:0070914
GO:0071987
GO:0080008
GO:0097602
GO:0140013
GO:0160072
GO:1901990
GO:2000242
Participates
as a component of
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
DDB1:DDB2 [nucleoplasm] (Canis familiaris)
DDB1:PAR-DDB2 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Inferred From
DDB1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_533275.2
OpenTargets
ENSG00000167986
Ensembl
ENSCAFP00845018193
,
ENSCAFG00845012984
,
ENSCAFT00845023200
© 2024
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