Reactome | CHD3 [nucleoplasm]

CHD3 [nucleoplasm]

Stable Identifier

R-CFA-4657012

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

CHD3, A0A8I3SA67

Locations in the PathwayBrowser

Expand all

Chromatin organization (Canis familiaris)

- Chromatin modifying enzymes (Canis familiaris)
  - HDACs deacetylate histones (Canis familiaris)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Canis familiaris)
      - HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        Mi-2 [nucleoplasm] (Canis familiaris)
        
        CHD3 [nucleoplasm] (Canis familiaris)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Canis familiaris)
        
        HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        Mi-2 [nucleoplasm] (Canis familiaris)
        
        CHD3 [nucleoplasm] (Canis familiaris)
    - HDAC1:2-containing complex deacetylate histones (Canis familiaris)
      - HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        Mi-2 [nucleoplasm] (Canis familiaris)
        
        CHD3 [nucleoplasm] (Canis familiaris)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Canis familiaris)
        
        HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        Mi-2 [nucleoplasm] (Canis familiaris)
        
        CHD3 [nucleoplasm] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase I Transcription (Canis familiaris)
  - RNA Polymerase I Promoter Clearance (Canis familiaris)
    - RNA Polymerase I Transcription Initiation (Canis familiaris)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Canis familiaris)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        Mi-2 [nucleoplasm] (Canis familiaris)
        
        CHD3 [nucleoplasm] (Canis familiaris)
- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional Regulation by TP53 (Canis familiaris)
      - Regulation of TP53 Activity (Canis familiaris)
        
        Regulation of TP53 Activity through Acetylation (Canis familiaris)
        
        MTA2-NuRD complex deacetylates TP53 (Canis familiaris)
        
        MTA2-NuRD complex [nucleoplasm] (Canis familiaris)
        
        Mi-2 [nucleoplasm] (Canis familiaris)
        
        CHD3 [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - PTEN Regulation (Canis familiaris)
      - Regulation of PTEN gene transcription (Canis familiaris)
        
        SALL4 recruits NuRD to PTEN gene (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        Mi-2 [nucleoplasm] (Canis familiaris)
        
        CHD3 [nucleoplasm] (Canis familiaris)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Canis familiaris)
        
        SALL4:NuRD [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        Mi-2 [nucleoplasm] (Canis familiaris)
        
        CHD3 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3SA67

Gene Names

CHD3

Reference Genes

ENSEMBL:ENSCAFG00845026255.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026255.1 CHD3

Other Identifiers

479489

Cfa.13135.1.A1_s_at

Cfa.14915.1.A1_x_at

Cfa.17229.1.S1_s_at

GO:0000122

GO:0000166

GO:0000976

GO:0003677

GO:0003824

GO:0004386

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0007010

GO:0007051

GO:0007098

GO:0016581

GO:0016605

GO:0016787

GO:0016887

GO:0034451

GO:0043226

GO:0046872

GO:0140097

GO:0140657

GO:0140658

Participates

as a member of

Mi-2 [nucleoplasm] (Canis familiaris)

Inferred From

CHD3 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000170004

Ensembl

ENSCAFG00845026255, ENSCAFP00845036698, ENSCAFT00845046782