Reactome | MAPK9 [cytosol]

MAPK9 [cytosol]

Stable Identifier

R-CFA-450355

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

MAPK9, A0A8I3MZT9

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-17 signaling (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - FCERI mediated MAPK activation (Canis familiaris)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK9 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MZT9

Gene Names

MAPK9

Reference Genes

ENSEMBL:ENSCAFG00845006710.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006710.1 MAPK9

Reference Transcript

RefSeq:XM_851205.4 MAPK9

Other Identifiers

474652

Cfa.10236.1.A1_at

CfaAffx.1558.1.S1_s_at

GO:0003824

GO:0004672

GO:0004707

GO:0005524

GO:0006468

GO:0016740

GO:0023052

GO:0036211

GO:0140096

Participates

as a member of

MAPK8,9,10 [cytosol] (Canis familiaris)

Other forms of this molecule

phospho-MAPK9 [cytosol]

phospho-MAPK9 [nucleoplasm]

Inferred From

MAPK9 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_856298.1

OpenTargets

ENSG00000050748

Ensembl

ENSCAFT00845011986, ENSCAFP00845009352, ENSCAFG00845006710

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