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IL12A [extracellular region]
Stable Identifier
R-CFA-447212
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
IL12A, A0A8I3PVB6
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-12 family signaling (Canis familiaris)
Interleukin-12 signaling (Canis familiaris)
IL12 bound to IL12R internalises (Canis familiaris)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL12A:IL12B translocates from late endosome lumen to extracellular region (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
Interleukin-12 binds Interleukin-12 receptor (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
Interleukin-12 dissociates from Interleukin-12 receptor (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Canis familiaris)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
Interleukin-35 Signalling (Canis familiaris)
IL35 binds IL-12RB2:IL6ST receptor (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35 binds IL12RB2:IL12RB2 receptor (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35 binds IL27RA:IL12RB2 receptor (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35 binds IL6ST:IL6ST receptor (Canis familiaris)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
Interleukin-35 translocates from the ER lumen to the extracellular region (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Canis familiaris)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Canis familiaris)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Canis familiaris)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Canis familiaris)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Canis familiaris)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Canis familiaris)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Canis familiaris)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Canis familiaris)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Canis familiaris)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
STAT1 associates with IL6ST:IL6ST (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Canis familiaris)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Canis familiaris)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
STAT4 binds IL12RB2:IL12RB2 (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
p-STAT1 dissociates from IL6ST:IL6ST (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Canis familiaris)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Canis familiaris)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
IL12A [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PVB6
Gene Names
IL12A
Reference Genes
BioGPS Gene:403977 IL12A
ENSEMBL:ENSCAFG00845026803.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026803.1 IL12A
KEGG Gene (Canis lupus familiaris):403977 IL12A
Monarch:403977 IL12A
NCBI Gene:403977 IL12A
Reference Transcript
RefSeq:NM_001003293.2 IL12A
Other Identifiers
403977
Cfa.3843.1.S1_s_at
GO:0001916
GO:0002376
GO:0002860
GO:0005125
GO:0005143
GO:0005576
GO:0005615
GO:0006955
GO:0007155
GO:0008083
GO:0009615
GO:0010224
GO:0012501
GO:0016477
GO:0023052
GO:0032496
GO:0032700
GO:0032729
GO:0032816
GO:0032946
GO:0034393
GO:0035722
GO:0036211
GO:0042163
GO:0042531
GO:0043514
GO:0045513
GO:0045785
GO:0045954
GO:0046982
GO:0048018
GO:0048662
GO:0048856
GO:0048870
GO:0050671
GO:0050709
GO:0050830
GO:0051135
GO:0097191
GO:0098542
GO:0098586
GO:0098772
GO:1900747
GO:1903588
GO:2000510
Participates
as a component of
IL35 [extracellular region] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
Other forms of this molecule
IL12A [endoplasmic reticulum lumen]
IL12A [late endosome lumen]
Inferred From
IL12A [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001003293.2
OpenTargets
ENSG00000168811
Ensembl
ENSCAFP00845037078
,
ENSCAFT00845047244
,
ENSCAFG00845026803
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