Reactome | GPR65 [plasma membrane]

GPR65 [plasma membrane]

Stable Identifier

R-CFA-444624

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

GPR65, E2RAY8

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (q) signalling events (Canis familiaris)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        pH sensing receptors:H+ [plasma membrane] (Canis familiaris)
        
        pH sensing receptors [plasma membrane] (Canis familiaris)
        
        GPR65 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        pH sensing receptors:H+ [plasma membrane] (Canis familiaris)
        
        pH sensing receptors [plasma membrane] (Canis familiaris)
        
        GPR65 [plasma membrane] (Canis familiaris)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        pH sensing receptors:H+ [plasma membrane] (Canis familiaris)
        
        pH sensing receptors [plasma membrane] (Canis familiaris)
        
        GPR65 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        pH sensing receptors:H+ [plasma membrane] (Canis familiaris)
        
        pH sensing receptors [plasma membrane] (Canis familiaris)
        
        GPR65 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
        
        GPCRs that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        pH sensing receptors [plasma membrane] (Canis familiaris)
        
        GPR65 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        pH sensing receptors:H+ [plasma membrane] (Canis familiaris)
        
        pH sensing receptors [plasma membrane] (Canis familiaris)
        
        GPR65 [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Canis familiaris)
        
        pH sensing receptors [plasma membrane] (Canis familiaris)
        
        GPR65 [plasma membrane] (Canis familiaris)
        
        pH sensing receptors:H+ [plasma membrane] (Canis familiaris)
        
        pH sensing receptors [plasma membrane] (Canis familiaris)
        
        GPR65 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RAY8

Gene Names

GPR65

Reference Genes

BioGPS Gene:490821 GPR65

ENSEMBL:ENSCAFG00000017342

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000017342 GPR65

KEGG Gene (Canis lupus familiaris):490821 GPR65

Monarch:490821 GPR65

NCBI Gene:490821 GPR65

Reference Transcript

Other Identifiers

490821

CfaAffx.26530.1.S1_at

GO:0003674

GO:0004930

GO:0005575

GO:0005886

GO:0005887

GO:0007010

GO:0007165

GO:0007186

GO:0007189

GO:0008150

GO:0010447

GO:0016020

GO:0016021

GO:0022607

GO:0031532

GO:0035025

GO:0042592

GO:0051482

GO:0051496

GO:0090630

Participant Of

hasMember

pH sensing receptors [plasma membrane]

Inferred From

GPR65 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005623780.1, XP_005623778.1

OpenTargets

ENSG00000140030

Ensembl

ENSCAFT00000027475, ENSCAFP00000025551, ENSCAFG00000017342

VGNC

41442