Reactome | SLC2A8 [plasma membrane]

SLC2A8 [plasma membrane]

Stable Identifier

R-CFA-429140

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

SLC2A8, A0A8I3MZL3

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - AP-2 directly binds some endocytic cargo (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        SLC2A8 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MZL3

Gene Names

SLC2A8

Reference Genes

ENSEMBL:ENSCAFG00845006645.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006645.1 SLC2A8

Other Identifiers

480717

Cfa.1428.1.A1_at

CfaAffx.30840.1.S1_at

CfaAffx.30841.1.S1_s_at

GO:0001666

GO:0005215

GO:0005353

GO:0005355

GO:0005536

GO:0005886

GO:0008286

GO:0015755

GO:0016020

GO:0022857

GO:0023052

GO:0033300

GO:0055085

GO:0070837

GO:1904659

Participates

as a member of

Other forms of this molecule

SLC2A8 [clathrin-coated endocytic vesicle membrane]

Inferred From

SLC2A8 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000136856

Ensembl

ENSCAFT00845011830, ENSCAFG00845006645, ENSCAFP00845009231

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