Reactome | GRM4 [plasma membrane]

GRM4 [plasma membrane]

Stable Identifier

R-CFA-420528

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

GRM4, A0A8I3PP20

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Canis familiaris)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Canis familiaris)
        
        GRM4 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Canis familiaris)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Canis familiaris)
        
        GRM4 [plasma membrane] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Canis familiaris)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Canis familiaris)
        
        GRM4 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Canis familiaris)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Canis familiaris)
        
        GRM4 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Canis familiaris)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Canis familiaris)
        
        GRM4 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Canis familiaris)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Canis familiaris)
        
        GRM4 [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Canis familiaris)
      - Metabotropic glutamate receptors bind glutamate (Canis familiaris)
        
        GRM1-8 [plasma membrane] (Canis familiaris)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Canis familiaris)
        
        GRM4 [plasma membrane] (Canis familiaris)
        
        GRM1-8:L-Glu [plasma membrane] (Canis familiaris)
        
        GRM1-8 [plasma membrane] (Canis familiaris)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Canis familiaris)
        
        GRM4 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PP20

Gene Names

GRM4

Reference Genes

ENSEMBL:ENSCAFG00845026257.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026257.1 GRM4

Other Identifiers

481749

CfaAffx.2697.1.S1_s_at

GO:0004930

GO:0005886

GO:0007154

GO:0007165

GO:0007186

GO:0007196

GO:0008066

GO:0016020

GO:0023052

GO:0031410

GO:0043226

GO:0043410

GO:0060089

Participates

as a member of

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Canis familiaris)

Inferred From

GRM4 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000124493

Ensembl

ENSCAFT00845046416, ENSCAFG00845026257, ENSCAFP00845036447