Reactome | DOCK1,TRIO [cytosol]

DOCK1,TRIO [cytosol]

Stable Identifier

R-CFA-418807

Type

Set [DefinedSet]

Species

Canis familiaris

Compartment

cytosol

Synonyms

Rho GEFs DOCK and TRIO, Rho GEFs DOCK and Trio

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Axon guidance (Canis familiaris)
  - Netrin-1 signaling (Canis familiaris)
    - DCC mediated attractive signaling (Canis familiaris)
      - Activation of Cdc42 (Canis familiaris)
        
        DOCK1,TRIO [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1,TRIO [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1,TRIO [cytosol] (Canis familiaris)
      - Activation of Rac1 (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1,TRIO [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1,TRIO [cytosol] (Canis familiaris)
      - Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1,TRIO [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1,TRIO [cytosol] (Canis familiaris)
      - RhoGTPase GEF's recruited to DCC (Canis familiaris)
        
        DOCK1,TRIO [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1,TRIO [cytosol] (Canis familiaris)

Participants

members

Participant Of

input

RhoGTPase GEF's recruited to DCC

hasComponent

NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]

Inferred From

DOCK1,TRIO [cytosol] (Homo sapiens)