Reactome | phospho-EPHA8 [plasma membrane]

phospho-EPHA8 [plasma membrane]

Stable Identifier

R-CFA-3928350

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

p-Y610,Y616-EPHA8, A0A8I3MB23

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - EPH-Ephrin signaling (Canis familiaris)
      - EPH receptors autophosphorylate (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        p-EPHAs [plasma membrane] (Canis familiaris)
        
        phospho-EPHA8 [plasma membrane] (Canis familiaris)
      - EPH-ephrin mediated repulsion of cells (Canis familiaris)
        
        EPHA binds TIAM1 (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        p-EPHAs [plasma membrane] (Canis familiaris)
        
        phospho-EPHA8 [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        p-EPHAs [plasma membrane] (Canis familiaris)
        
        phospho-EPHA8 [plasma membrane] (Canis familiaris)
        
        SFKs phosphorylate VAV2,3 (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        p-EPHAs [plasma membrane] (Canis familiaris)
        
        phospho-EPHA8 [plasma membrane] (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        p-EPHAs [plasma membrane] (Canis familiaris)
        
        phospho-EPHA8 [plasma membrane] (Canis familiaris)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        p-EPHAs [plasma membrane] (Canis familiaris)
        
        phospho-EPHA8 [plasma membrane] (Canis familiaris)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        p-EPHAs [plasma membrane] (Canis familiaris)
        
        phospho-EPHA8 [plasma membrane] (Canis familiaris)
        
        p-EPHs bind VAV2,3 (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        p-EPHAs [plasma membrane] (Canis familiaris)
        
        phospho-EPHA8 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        p-EPHAs [plasma membrane] (Canis familiaris)
        
        phospho-EPHA8 [plasma membrane] (Canis familiaris)
      - EPHA-mediated growth cone collapse (Canis familiaris)
        
        NGEF exchanges GTP for GDP on RHOA (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        p-EPHAs [plasma membrane] (Canis familiaris)
        
        phospho-EPHA8 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MB23

Gene Names

EPHA8

Reference Genes

ENSEMBL:ENSCAFG00845000509.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845000509.1 EPHA8

Other Identifiers

487383

CfaAffx.22555.1.S1_at

GO:0003824

GO:0004672

GO:0004713

GO:0005003

GO:0005004

GO:0005515

GO:0005524

GO:0005886

GO:0006468

GO:0006929

GO:0007155

GO:0007169

GO:0007411

GO:0016020

GO:0016322

GO:0016740

GO:0019838

GO:0023052

GO:0030154

GO:0030155

GO:0031175

GO:0033628

GO:0036211

GO:0043005

GO:0043410

GO:0048013

GO:0048856

GO:0048870

GO:0051897

GO:0060089

GO:0071372

GO:0140096

Participates

as a member of

p-EPHAs [plasma membrane] (Canis familiaris)

Other forms of this molecule

EPHA8 [plasma membrane]

Inferred From

p-Y610,Y616-EPHA8 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 610 (in Homo sapiens)

Coordinate

610

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 616 (in Homo sapiens)

Coordinate

616

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000070886

Ensembl

ENSCAFT00845000932, ENSCAFP00845000701, ENSCAFG00845000509

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