Reactome | PIK3CD [plasma membrane]

PIK3CD [plasma membrane]

Stable Identifier

R-CFA-392274

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

PIK3CD, A0A8I3Q525

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - RET signaling (Canis familiaris)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Regulation of T cell activation by CD28 family (Canis familiaris)
    - Co-stimulation by CD28 (Canis familiaris)
      - CD28 dependent PI3K/Akt signaling (Canis familiaris)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        PI3K binds CD28 (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
    - Co-stimulation by ICOS (Canis familiaris)
      - PI3K binds ICOS (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        ICOS:PI3K [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
  - Signaling by the B Cell Receptor (BCR) (Canis familiaris)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
      - BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
        
        BCAP Signalosome [plasma membrane] (Canis familiaris)
        
        PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
      - CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
        
        CD19 Signalosome [plasma membrane] (Canis familiaris)
        
        PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
      - p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)
        
        CD19 Signalosome [plasma membrane] (Canis familiaris)
        
        PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-2 family signaling (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
      - 14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
      - Regulation of signaling by CBL (Canis familiaris)
        
        CBL ubiquitinates PI3K (Canis familiaris)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        K63polyUb-PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        Activator:PI3K [plasma membrane] (Canis familiaris)
        
        BCAP Signalosome [plasma membrane] (Canis familiaris)
        
        PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        CD19 Signalosome [plasma membrane] (Canis familiaris)
        
        PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        ICOS:PI3K [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - Activator:PI3K [plasma membrane] (Canis familiaris)
        
        BCAP Signalosome [plasma membrane] (Canis familiaris)
        
        PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        CD19 Signalosome [plasma membrane] (Canis familiaris)
        
        PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)
        
        ICOS:PI3K [plasma membrane] (Canis familiaris)
        
        Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        PI3K delta [cytosol] (Canis familiaris)
        
        PIK3CD [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q525

Gene Names

PIK3CD

Reference Genes

BioGPS Gene:489644 PIK3CD

ENSEMBL:ENSCAFG00845028970.1

KEGG:cfa:489644 PIK3CD

Monarch:489644 PIK3CD

NCBI Gene:489644 PIK3CD

UCSC:A0A8I3Q525 PIK3CD

Reference Transcript

Other Identifiers

489644

CfaAffx.30189.1.S1_s_at

GO:0000166

GO:0001938

GO:0002250

GO:0002376

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005943

GO:0006629

GO:0006935

GO:0006954

GO:0007166

GO:0010595

GO:0010628

GO:0016301

GO:0016303

GO:0016477

GO:0016740

GO:0022603

GO:0030154

GO:0030335

GO:0033031

GO:0035005

GO:0036092

GO:0038084

GO:0042113

GO:0043491

GO:0045087

GO:0046854

GO:0048015

GO:0048870

GO:0051094

GO:0051240

GO:0098542

GO:1905278

GO:2000026

Participates

as a component of

Other forms of this molecule

PIK3CD [cytosol]

Inferred From

PIK3CD [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005620565.1, XP_005620564.1, XP_546764.2, XP_005620563.1, XP_038522589.1, XP_038393845.1

ENSEMBL

ENSCAFP00845040179, ENSCAFT00845051229, ENSCAFG00845028970

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