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PIK3CD [plasma membrane]
Stable Identifier
R-CFA-392274
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
PIK3CD, A0A8I3Q525
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
RET signaling (Canis familiaris)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
BCAP Signalosome [plasma membrane] (Canis familiaris)
PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
CD19 Signalosome [plasma membrane] (Canis familiaris)
PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)
CD19 Signalosome [plasma membrane] (Canis familiaris)
PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-2 family signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
Regulation of signaling by CBL (Canis familiaris)
CBL ubiquitinates PI3K (Canis familiaris)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
K63polyUb-PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
BCAP Signalosome [plasma membrane] (Canis familiaris)
PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
CD19 Signalosome [plasma membrane] (Canis familiaris)
PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
BCAP Signalosome [plasma membrane] (Canis familiaris)
PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
CD19 Signalosome [plasma membrane] (Canis familiaris)
PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CD [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3Q525
Gene Names
PIK3CD
Reference Genes
BioGPS Gene:489644 PIK3CD
ENSEMBL:ENSCAFG00845028970.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845028970.1 PIK3CD
KEGG Gene (Canis lupus familiaris):489644 PIK3CD
Monarch:489644 PIK3CD
NCBI Gene:489644 PIK3CD
Reference Transcript
RefSeq:XM_546764.5 PIK3CD
RefSeq:XM_005620507.2 PIK3CD
RefSeq:XM_005620508.2 PIK3CD
RefSeq:XM_005620506.2 PIK3CD
Other Identifiers
489644
CfaAffx.30189.1.S1_s_at
GO:0000166
GO:0001938
GO:0002376
GO:0003824
GO:0005524
GO:0005943
GO:0006629
GO:0010595
GO:0010628
GO:0012501
GO:0014065
GO:0016301
GO:0016303
GO:0016310
GO:0016740
GO:0023052
GO:0030335
GO:0033031
GO:0035004
GO:0036092
GO:0038089
GO:0043491
GO:0046854
GO:0048015
GO:0048856
GO:0048870
GO:1905278
Participates
as a component of
K63polyUb-PI3K delta [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [plasma membrane] (Canis familiaris)
Other forms of this molecule
PIK3CD [cytosol]
Inferred From
PIK3CD [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_005620563.1
,
XP_546764.2
,
XP_005620565.1
,
XP_005620564.1
OpenTargets
ENSG00000171608
Ensembl
ENSCAFT00845051229
,
ENSCAFG00845028970
,
ENSCAFP00845040179
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