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phospho-MAP3K8 [cytosol]
Stable Identifier
R-CFA-389738
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-S400-MAP3K8, A0A8I3N8I4
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
p-S400-Cot phosphorylates NIK (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
phospho-MAP3K8 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N8I4
Gene Names
MAP3K8
Reference Genes
BioGPS Gene:487085 MAP3K8
ENSEMBL:ENSCAFG00845011569.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845011569.1 MAP3K8
KEGG Gene (Canis lupus familiaris):487085 MAP3K8
Monarch:487085 MAP3K8
NCBI Gene:487085 MAP3K8
Reference Transcript
RefSeq:XM_005617057.2 MAP3K8
RefSeq:XM_544213.5 MAP3K8
RefSeq:XM_005617056.2 MAP3K8
RefSeq:XM_014122101.1 MAP3K8
Other Identifiers
487085
CfaAffx.6888.1.S1_at
GO:0003824
GO:0004672
GO:0005524
GO:0005829
GO:0006468
GO:0016740
GO:0036211
GO:0140096
Participates
as a component of
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
Other forms of this molecule
MAP3K8 [cytosol]
phospho-MAP3K8 [cytosol]
Inferred From
p-S400-MAP3K8 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 400 (in Homo sapiens)
Coordinate
400
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_013977576.1
,
XP_005617113.1
,
XP_005617114.1
,
XP_544213.3
OpenTargets
ENSG00000107968
Ensembl
ENSCAFP00845016086
,
ENSCAFT00845020516
,
ENSCAFG00845011569
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