Reactome | BMI1 [nucleoplasm]

BMI1 [nucleoplasm]

Stable Identifier

R-CFA-389121

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

BMI1, A0A8I3MY48

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional Regulation by E2F6 (Canis familiaris)
      - E2F6 binds the PRC1 complex (Canis familiaris)
        
        E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Canis familiaris)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Canis familiaris)
        
        BMI1,PCGF2 [nucleoplasm] (Canis familiaris)
        
        BMI1 [nucleoplasm] (Canis familiaris)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Canis familiaris)
        
        BMI1,PCGF2 [nucleoplasm] (Canis familiaris)
        
        BMI1 [nucleoplasm] (Canis familiaris)
    - Transcriptional regulation by RUNX1 (Canis familiaris)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Canis familiaris)
        
        RUNX1 binds PRC1 complexes (Canis familiaris)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Canis familiaris)
        
        PRC1.4 [nucleoplasm] (Canis familiaris)
        
        BMI1 [nucleoplasm] (Canis familiaris)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Canis familiaris)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Canis familiaris)
        
        PRC1.4 [nucleoplasm] (Canis familiaris)
        
        BMI1 [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - PTEN Regulation (Canis familiaris)
      - Regulation of PTEN gene transcription (Canis familiaris)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Canis familiaris)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Canis familiaris)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Canis familiaris)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Canis familiaris)
        
        PRC1.4 [nucleoplasm] (Canis familiaris)
        
        BMI1 [nucleoplasm] (Canis familiaris)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Canis familiaris)
        
        PRC1.4 [nucleoplasm] (Canis familiaris)
        
        BMI1 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MY48

Gene Names

BMI1

Reference Genes

BioGPS Gene:487097 BMI1

ENSEMBL:ENSCAFG00845008000.1

KEGG:cfa:487097 BMI1

Monarch:487097 BMI1

NCBI Gene:487097 BMI1

UCSC:A0A8I3MY48 BMI1

Reference Transcript

Other Identifiers

477977

487097

Cfa.8948.1.A1_at

CfaAffx.7152.1.S1_s_at

CfaAffx.7166.1.S1_s_at

GO:0000122

GO:0000151

GO:0000792

GO:0001501

GO:0001701

GO:0002376

GO:0003682

GO:0005634

GO:0005829

GO:0006325

GO:0006338

GO:0006346

GO:0006355

GO:0006814

GO:0006959

GO:0007420

GO:0008270

GO:0010468

GO:0016604

GO:0021903

GO:0030097

GO:0030890

GO:0031519

GO:0033092

GO:0035102

GO:0045814

GO:0046872

GO:0048103

GO:0048146

GO:0048704

GO:0048706

GO:0048856

GO:0071535

GO:0097027

GO:0097190

GO:0098772

GO:1990841

GO:2000011

GO:2001234

Participates

as a member of

BMI1,PCGF2 [nucleoplasm] (Canis familiaris)

as a component of

PRC1.4 [nucleoplasm] (Canis familiaris)

Other forms of this molecule

phospho-BMI1 [nucleoplasm]

Inferred From

BMI1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001273992.1, XP_005617072.1, XP_005617071.1

ENSEMBL

ENSCAFT00845014096, ENSCAFP00845010926, ENSCAFG00845008000