Reactome | CBX2 [nucleoplasm]

CBX2 [nucleoplasm]

Stable Identifier

R-CFA-389110

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

CBX2, A0A8I3NS11

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular Senescence (Canis familiaris)
    - Oxidative Stress Induced Senescence (Canis familiaris)
      - PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Canis familiaris)
        
        CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Canis familiaris)
        
        PRC1.4 [nucleoplasm] (Canis familiaris)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Canis familiaris)
        
        CBX2 [nucleoplasm] (Canis familiaris)
        
        PRC1.4 [nucleoplasm] (Canis familiaris)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Canis familiaris)
        
        CBX2 [nucleoplasm] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional regulation by RUNX1 (Canis familiaris)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Canis familiaris)
        
        RUNX1 binds PRC1 complexes (Canis familiaris)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Canis familiaris)
        
        PRC1.4 [nucleoplasm] (Canis familiaris)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Canis familiaris)
        
        CBX2 [nucleoplasm] (Canis familiaris)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Canis familiaris)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Canis familiaris)
        
        PRC1.4 [nucleoplasm] (Canis familiaris)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Canis familiaris)
        
        CBX2 [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - PTEN Regulation (Canis familiaris)
      - Regulation of PTEN gene transcription (Canis familiaris)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Canis familiaris)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Canis familiaris)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Canis familiaris)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Canis familiaris)
        
        PRC1.4 [nucleoplasm] (Canis familiaris)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Canis familiaris)
        
        CBX2 [nucleoplasm] (Canis familiaris)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Canis familiaris)
        
        PRC1.4 [nucleoplasm] (Canis familiaris)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Canis familiaris)
        
        CBX2 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NS11

Gene Names

CBX2

Reference Genes

ENSEMBL:ENSCAFG00845013965.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845013965.1 CBX2

Other Identifiers

483349

CfaAffx.9288.1.S1_at

GO:0000122

GO:0000791

GO:0000792

GO:0003682

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0022414

GO:0031519

GO:0035064

GO:0035102

GO:0042393

GO:0043226

GO:0045137

GO:0048856

Participates

as a member of

Inferred From

CBX2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000173894

Ensembl

ENSCAFP00845019638, ENSCAFG00845013965, ENSCAFT00845024966