Reactome | PRKAB1 [cytosol]

PRKAB1 [cytosol]

Stable Identifier

R-CFA-380968

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

PRKAB1, A0A8I3PY75

Locations in the PathwayBrowser

Expand all

Autophagy (Canis familiaris)

- Macroautophagy (Canis familiaris)
  - AMPK (complex) phosphorylates ULK1 (complex) (Canis familiaris)
    - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
  - Thr-180 of ULK1 is phosphorylated (Canis familiaris)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
  - ULK complex translocates to the ER (Canis familiaris)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Canis familiaris)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Canis familiaris)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
  - ULK1 phosphorylates Beclin-1 (Canis familiaris)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
  - p-AMPK:AMP binds the ULK complex (Canis familiaris)
    - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Canis familiaris)
    - p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
      - p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional Regulation by TP53 (Canis familiaris)
      - TP53 Regulates Metabolic Genes (Canis familiaris)
        
        SESN1,2,3 bind AMPK (Canis familiaris)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)
        
        p-AMPK phosphorylates TSC1:TSC2 (Canis familiaris)
        
        p-AMPK heterotrimer:AMP [cytosol] (Canis familiaris)
        
        p-AMPK heterotrimer [cytosol] (Canis familiaris)
        
        AMPK beta [cytosol] (Canis familiaris)
        
        PRKAB1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PY75

Gene Names

PRKAB1

Reference Genes

BioGPS Gene:486295 PRKAB1

ENSEMBL:ENSCAFG00845028956.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845028956.1 PRKAB1

KEGG Gene (Canis lupus familiaris):486295 PRKAB1

Monarch:486295 PRKAB1

NCBI Gene:486295 PRKAB1

Reference Transcript

RefSeq:XM_543421.5 PRKAB1

Other Identifiers

486295

Cfa.17338.1.S1_at

Cfa.17338.1.S1_s_at

CfaAffx.15678.1.S1_at

CfaAffx.15688.1.S1_s_at

GO:0003824

GO:0004672

GO:0005515

GO:0005634

GO:0010628

GO:0016740

GO:0031588

GO:0031669

GO:0035878

GO:0043226

GO:0048856

GO:0120162

GO:0140096

Participates

as a member of

AMPK beta [cytosol] (Canis familiaris)

Other forms of this molecule

PRKAB1 [nucleoplasm]

Inferred From

PRKAB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_543421.2

OpenTargets

ENSG00000111725

Ensembl

ENSCAFP00845040145, ENSCAFG00845028956, ENSCAFT00845051187

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