Reactome | ADCY4 [plasma membrane]

ADCY4 [plasma membrane]

Stable Identifier

R-CFA-379054

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

A0A8I3RTR3

Locations in the PathwayBrowser

Expand all

Neuronal System (Canis familiaris)

- Transmission across Chemical Synapses (Canis familiaris)
  - Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
    - GABA receptor activation (Canis familiaris)
      - GABA B receptor activation (Canis familiaris)
        
        Activation of GABAB receptors (Canis familiaris)
        
        Adenylate cyclase inhibitory pathway (Canis familiaris)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        Dissociation of the Gi alpha:G olf complex (Canis familiaris)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - DAG and IP3 signaling (Canis familiaris)
    - CaM pathway (Canis familiaris)
      - Calmodulin induced events (Canis familiaris)
        
        PKA-mediated phosphorylation of CREB (Canis familiaris)
        
        PKA activation (Canis familiaris)
        
        Adenylate cyclase produces cAMP (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Opioid Signalling (Canis familiaris)
        
        G-protein mediated events (Canis familiaris)
        
        Adenylate cyclase activating pathway (Canis familiaris)
        
        Adenylate cyclase converts ATP into cyclic AMP (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase inhibitory pathway (Canis familiaris)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        Dissociation of the Gi alpha:G olf complex (Canis familiaris)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        PLC beta mediated events (Canis familiaris)
        
        Ca-dependent events (Canis familiaris)
        
        CaM pathway (Canis familiaris)
        
        Calmodulin induced events (Canis familiaris)
        
        PKA-mediated phosphorylation of CREB (Canis familiaris)
        
        PKA activation (Canis familiaris)
        
        Adenylate cyclase produces cAMP (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
    - G alpha (z) signalling events (Canis familiaris)
      - G alpha (z) inhibits adenylate cyclase (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)
- Signaling by Hedgehog (Canis familiaris)
  - Hedgehog 'off' state (Canis familiaris)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Canis familiaris)
      - adenylate cyclases:Mg2+ [plasma membrane] (Canis familiaris)
        
        adenylate cyclases [plasma membrane] (Canis familiaris)
        
        ADCY4 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RTR3

Reference Genes

BioGPS Gene:480271

ENSEMBL:ENSCAFG00845007125.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845007125.1

Monarch:480271

NCBI Gene:480271

Reference Transcript

RefSeq:XM_537394.5

Other Identifiers

480271

CfaAffx.19151.1.S1_s_at

GO:0000166

GO:0003824

GO:0004016

GO:0005080

GO:0005524

GO:0005737

GO:0005886

GO:0006171

GO:0007188

GO:0009190

GO:0009975

GO:0016020

GO:0016829

GO:0016849

GO:0023052

GO:0030425

GO:0035556

GO:0046872

GO:0055086

GO:1901135

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Canis familiaris)

as a member of

Adenylate cyclase [plasma membrane] (Canis familiaris)

Inferred From

ADCY4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_537394.2

Ensembl

ENSCAFT00845012649, ENSCAFG00845007125, ENSCAFP00845009870

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