Reactome | CENPF [cytosol]

CENPF [cytosol]

Stable Identifier

R-CFA-376229

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

CENPF, A0A8I3MZV9

Locations in the PathwayBrowser

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Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - Mitotic Spindle Checkpoint (Canis familiaris)
    - Amplification of signal from the kinetochores (Canis familiaris)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Canis familiaris)
        
        MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Mad1 binds kinetochore (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Release of activated MAD2 from kinetochores (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
- Cell Cycle, Mitotic (Canis familiaris)
  - M Phase (Canis familiaris)
    - Mitotic Metaphase and Anaphase (Canis familiaris)
      - Mitotic Anaphase (Canis familiaris)
        
        Separation of Sister Chromatids (Canis familiaris)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Separation of sister chromatids (Canis familiaris)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
    - Mitotic Prometaphase (Canis familiaris)
      - EML4 and NUDC in mitotic spindle formation (Canis familiaris)
        
        EML4 recruits NUDC to mitotic spindle (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
      - Kinetochore capture of astral microtubules (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
      - Resolution of Sister Chromatid Cohesion (Canis familiaris)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Kinetochore assembly (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CENPF [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MZV9

Gene Names

CENPF

Reference Genes

ENSEMBL:ENSCAFG00845001752.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845001752.1 CENPF

Other Identifiers

480027

CfaAffx.19526.1.S1_at

CfaAffx.19534.1.S1_at

CfaAffx.19540.1.S1_at

GO:0000278

GO:0000775

GO:0000776

GO:0000922

GO:0000940

GO:0001822

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005929

GO:0005930

GO:0006351

GO:0006355

GO:0007059

GO:0008017

GO:0008092

GO:0008134

GO:0010389

GO:0015031

GO:0016202

GO:0016363

GO:0021591

GO:0030496

GO:0031965

GO:0036064

GO:0042803

GO:0043226

GO:0045120

GO:0045892

GO:0048856

GO:0051310

GO:0070840

GO:0097539

GO:0140297

Participates

as a component of

Kinetochore [cytosol] (Canis familiaris)

Inferred From

CENPF [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000117724

Ensembl

ENSCAFP00845002458, ENSCAFG00845001752, ENSCAFT00845003077

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