Reactome | GRP [extracellular region]

GRP [extracellular region]

Stable Identifier

R-CFA-375358

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

GRP(24-50), A0A8I3RQW9

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (q) signalling events (Canis familiaris)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like peptide [extracellular region] (Canis familiaris)
        
        GRP [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like peptide [extracellular region] (Canis familiaris)
        
        GRP [extracellular region] (Canis familiaris)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like peptide [extracellular region] (Canis familiaris)
        
        GRP [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like peptide [extracellular region] (Canis familiaris)
        
        GRP [extracellular region] (Canis familiaris)
      - The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like peptide [extracellular region] (Canis familiaris)
        
        GRP [extracellular region] (Canis familiaris)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Canis familiaris)
        
        Bombesin-like peptide [extracellular region] (Canis familiaris)
        
        GRP [extracellular region] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Peptide ligand-binding receptors (Canis familiaris)
        
        Bombesin-like receptors bind bombesin homologues (Canis familiaris)
        
        Bombesin-like peptide [extracellular region] (Canis familiaris)
        
        GRP [extracellular region] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like peptide [extracellular region] (Canis familiaris)
        
        GRP [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RQW9

Gene Names

GRP

Reference Genes

ENSEMBL:ENSCAFG00845000570.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845000570.1 GRP

Other Identifiers

610154

CfaAffx.1115.1.S1_at

CfaAffx.1115.1.S1_s_at

CfaAffx.1116.1.S1_at

GO:0002376

GO:0005184

GO:0005576

GO:0005615

GO:0007218

GO:0016192

GO:0023052

GO:0035176

GO:0036343

GO:0043005

GO:0043207

GO:0043303

GO:0048018

GO:0098772

GO:1900738

GO:1903942

GO:2000987

Participates

as a member of

Bombesin-like peptide [extracellular region] (Canis familiaris)

This entity regulates

Positively

Glucagon-like Peptide 1 is secreted from intestinal L cells (Canis familiaris)

Inferred From

GRP(24-50) [extracellular region] (Homo sapiens)

Cross References

OpenTargets

ENSG00000134443

Ensembl

ENSCAFG00845000570, ENSCAFT00845000914, ENSCAFP00845000684