Reactome | COL7A1 [extracellular region]

COL7A1 [extracellular region]

Stable Identifier

R-CFA-3605708

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL7A1(17-2821), F1PIP7

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Canis familiaris)

- Collagen formation (Canis familiaris)
  - Assembly of collagen fibrils and other multimeric structures (Canis familiaris)
    - Anchoring fibril formation (Canis familiaris)
      - Cleavage of collagen VII NC2 region by BMP1 (Canis familiaris)
        
        Collagen type VII -NC2 hexamer [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 trimer [extracellular region] (Canis familiaris)
        
        COL7A1 [extracellular region] (Canis familiaris)
      - Formation of anchoring fibrils (Canis familiaris)
        
        Collagen type VII -NC2 hexamer [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 trimer [extracellular region] (Canis familiaris)
        
        COL7A1 [extracellular region] (Canis familiaris)
        
        Collagen type VII fibril [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 hexamer [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 trimer [extracellular region] (Canis familiaris)
        
        COL7A1 [extracellular region] (Canis familiaris)
    - Hemidesmosome formation (Canis familiaris)
      - Collagen type VII fibril:Laminin-332 [extracellular region] (Canis familiaris)
        
        Collagen type VII fibril [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 hexamer [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 trimer [extracellular region] (Canis familiaris)
        
        COL7A1 [extracellular region] (Canis familiaris)
      - Type I hemidesmosome complex [extracellular region] (Canis familiaris)
        
        Collagen type VII fibril:Laminin-332 [extracellular region] (Canis familiaris)
        
        Collagen type VII fibril [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 hexamer [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 trimer [extracellular region] (Canis familiaris)
        
        COL7A1 [extracellular region] (Canis familiaris)
- Degradation of the extracellular matrix (Canis familiaris)
  - Collagen degradation (Canis familiaris)
    - Collagen type VII degradation by MMP1,2,3 (Canis familiaris)
      - Collagen type VII fibril [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 hexamer [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 trimer [extracellular region] (Canis familiaris)
        
        COL7A1 [extracellular region] (Canis familiaris)
- Integrin cell surface interactions (Canis familiaris)
  - Collagen type VII binds integrin alpha2beta1 (Canis familiaris)
    - Collagen type VII fibril [extracellular region] (Canis familiaris)
      - Collagen type VII -NC2 hexamer [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 trimer [extracellular region] (Canis familiaris)
        
        COL7A1 [extracellular region] (Canis familiaris)
    - Collagen type VII fibril:Integrin alpha2beta1 [plasma membrane] (Canis familiaris)
      - Collagen type VII fibril [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 hexamer [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 trimer [extracellular region] (Canis familiaris)
        
        COL7A1 [extracellular region] (Canis familiaris)
- Laminin interactions (Canis familiaris)
  - Laminin-332 binds collagen type VII (Canis familiaris)
    - Collagen type VII fibril [extracellular region] (Canis familiaris)
      - Collagen type VII -NC2 hexamer [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 trimer [extracellular region] (Canis familiaris)
        
        COL7A1 [extracellular region] (Canis familiaris)
    - Collagen type VII fibril:Laminin-332 [extracellular region] (Canis familiaris)
      - Collagen type VII fibril [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 hexamer [extracellular region] (Canis familiaris)
        
        Collagen type VII -NC2 trimer [extracellular region] (Canis familiaris)
        
        COL7A1 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1PIP7

Gene Names

COL7A1

Reference Genes

BioGPS Gene:403467 COL7A1

ENSEMBL:ENSCAFG00000012403

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000012403 COL7A1

Monarch:403467 COL7A1

NCBI Gene:403467 COL7A1

Reference Transcript

RefSeq:XM_005632303.2 COL7A1

Other Identifiers

403467

Cfa.178.1.S1_s_at

CfaAffx.19284.1.S1_s_at

GO:0003674

GO:0004867

GO:0005575

GO:0005576

GO:0005581

GO:0005615

GO:0007155

GO:0008150

GO:0010951

GO:0030234

GO:0031012

GO:0032991

GO:0062023

Participant Of

hasComponent

Collagen type VII -NC2 trimer [extracellular region]

Other forms of this molecule

COL7A1 [endoplasmic reticulum lumen]

COL7A1 [extracellular region]

COL7A1 [plasma membrane]

COL7A1 [extracellular region]

COL7A1 [plasma membrane]

COL7A1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

COL7A1 [COPII-coated ER to Golgi transport vesicle]

COL7A1 [extracellular region]

COL7A1 [endoplasmic reticulum lumen]

COL7A1 [COPII-coated ER to Golgi transport vesicle]

Inferred From

3x4Hyp-3Hyp-GalHyl-COL7A1(17-2821) [extracellular region] (Homo sapiens)

Collagen alpha-1(VII) -NC2 chains [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

XP_005632360.1

OpenTargets

ENSG00000114270

Ensembl

ENSCAFP00000018349, ENSCAFG00000012403, ENSCAFT00000019781

VGNC

39483

Cite Us!