Reactome | LYN [cytosol]

LYN [cytosol]

Stable Identifier

R-CFA-354251

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

A0A5F4C1A0

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - EPH-Ephrin signaling (Canis familiaris)
      - EPH-ephrin mediated repulsion of cells (Canis familiaris)
        
        EPHA binds TIAM1 (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        SFKs phosphorylate VAV2,3 (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        p-EPHs bind VAV2,3 (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPHA-mediated growth cone collapse (Canis familiaris)
        
        NGEF exchanges GTP for GDP on RHOA (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPHB-mediated forward signaling (Canis familiaris)
        
        EPHB phosphorylates TIAM1 (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EPHB:NMDAR binds TIAM1 (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Erythropoietin (Canis familiaris)
  - EPOR binds EPOR agonists (Canis familiaris)
    - EPOR agonists:EPOR:JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
      - EPOR:JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPOR:JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
      - LYN [cytosol] (Canis familiaris)
  - Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - PI3K bound to EPOR [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
  - Erythropoietin activates RAS (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by SCF-KIT (Canis familiaris)
    - Dimerization of STATs (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Disassociation and translocation of STATs to the nucleus (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Canis familiaris)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Indirect recruitment of GAB2 to p-KIT (Canis familiaris)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - JAK2 binds to p-KIT (Canis familiaris)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation and activation of VAV1 (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation of GAB2 by SFKs (Canis familiaris)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation of JAK2 (Canis familiaris)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation of SHP2 by SFKs (Canis familiaris)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation of STATs (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Canis familiaris)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Recruitment of STATs (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Regulation of KIT signaling (Canis familiaris)
      - Interaction of APS and p-KIT (Canis familiaris)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Phosphorylation of APS (Canis familiaris)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Recruitment of CBL to KIT (Canis familiaris)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - SHP2 interacts with p-KIT (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A5F4C1A0

Reference Genes

ENSEMBL:ENSCAFG00000007034

Participates

as a component of

as a member of

as a candidate of

FYN-like kinases [cytosol] (Canis familiaris)

as an input of

GPVI binds Fyn and Lyn (Canis familiaris)

Other forms of this molecule

MyrG2-PalmC3-LYN [lysosomal membrane]

MyrG2-PalmC3-LYN [endocytic vesicle membrane]

LYN [plasma membrane]

phospho-p-Y397-LYN [cytosol]

phospho-p-Y396-LYN [plasma membrane]

MyrG2-PalmC3-LYN [plasma membrane]

Inferred From

LYN [cytosol] (Homo sapiens)

Cross References

VGNC

42882

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