Reactome | LYN [cytosol]

LYN [cytosol]

Stable Identifier

R-CFA-354251

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

E2RBB8

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Axon guidance (Canis familiaris)
  - EPH-Ephrin signaling (Canis familiaris)
    - EPH-ephrin mediated repulsion of cells (Canis familiaris)
      - EPHA binds TIAM1 (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - SFKs phosphorylate VAV2,3 (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-EPHs bind VAV2,3 (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPHA-mediated growth cone collapse (Canis familiaris)
      - NGEF exchanges GTP for GDP on RHOA (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPHB-mediated forward signaling (Canis familiaris)
      - EPHB phosphorylates TIAM1 (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPHB:NMDAR binds TIAM1 (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        SRC,FYN,YES,LYN [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Erythropoietin (Canis familiaris)
  - Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - PI3K bound to EPOR [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
  - Erythropoietin activates RAS (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by SCF-KIT (Canis familiaris)
    - Dimerization of STATs (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Disassociation and translocation of STATs to the nucleus (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Canis familiaris)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Indirect recruitment of GAB2 to p-KIT (Canis familiaris)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - JAK2 binds to p-KIT (Canis familiaris)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation and activation of VAV1 (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation of GAB2 by SFKs (Canis familiaris)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation of JAK2 (Canis familiaris)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation of SHP2 by SFKs (Canis familiaris)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation of STATs (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Canis familiaris)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Recruitment of STATs (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Regulation of KIT signaling (Canis familiaris)
      - Interaction of APS and p-KIT (Canis familiaris)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Phosphorylation of APS (Canis familiaris)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - Recruitment of CBL to KIT (Canis familiaris)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - SHP2 interacts with p-KIT (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)
    - Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LYN [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RBB8

Reference Genes

BioGPS Gene:477886

dbSNP Gene:477886

ENSEMBL:ENSCAFG00000007034

Monarch:477886

NCBI Gene:477886

Reference Transcript

RefSeq:XM_535078.5

Other Identifiers

477886

AAEX03015802

Cfa.1835.1.S1_at

CfaAffx.11437.1.S1_s_at

ENSCAFG00000007034

ENSCAFP00000010452

ENSCAFT00000011282

EntrezGene:477886

GO:0000166

GO:0001782

GO:0001817

GO:0001933

GO:0001934

GO:0002376

GO:0002431

GO:0002513

GO:0002576

GO:0002762

GO:0002768

GO:0002774

GO:0002902

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005794

GO:0005886

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006950

GO:0006974

GO:0007155

GO:0007165

GO:0007169

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009725

GO:0010976

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0017124

GO:0018108

GO:0030097

GO:0030154

GO:0030218

GO:0030335

GO:0030889

GO:0031175

GO:0031234

GO:0031663

GO:0033003

GO:0033628

GO:0034136

GO:0034144

GO:0035556

GO:0038083

GO:0040011

GO:0042531

GO:0042592

GO:0043167

GO:0043226

GO:0043231

GO:0043304

GO:0043407

GO:0043552

GO:0044325

GO:0044877

GO:0045121

GO:0045646

GO:0046777

GO:0046875

GO:0048471

GO:0048856

GO:0048870

GO:0050707

GO:0050727

GO:0050731

GO:0050853

GO:0050855

GO:0050861

GO:0051272

GO:0051279

GO:0055085

GO:0070304

GO:0070372

GO:0070373

GO:0070667

GO:0070668

GO:0071300

GO:0090025

GO:0090330

GO:0097028

GO:0140031

GO:1902532

GO:1902961

GO:2000670

IPR000719

IPR000980

IPR001245

IPR001452

IPR008266

IPR011009

IPR017441

IPR020635

LYN

PF00017

PF00018

PF07714

PR00109

PR00401

PR00452

SM00219

SM00252

SM00326

UPI00004BEC5E

XM_005637999

XM_535078

XP_005638056

XP_535078

Participant Of

hasCandidate

FYN-like kinases [cytosol]

hasMember

input

GPVI binds Fyn and Lyn

hasComponent

Other forms of this molecule

LYN [plasma membrane]

phospho-p-Y397-LYN [cytosol]

MyrG2-PalmC3-LYN [plasma membrane]

phospho-p-Y396-LYN [plasma membrane]

Inferred From

LYN [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_535078.2