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LRP2 [plasma membrane]
Stable Identifier
R-CFA-350083
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
LRP2, A0A8I3PKW5
Locations in the PathwayBrowser
Expand all
Metabolism (Canis familiaris)
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of fat-soluble vitamins (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)
LRPs [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Transport of RCbl within the body (Canis familiaris)
LRP2 binds extracellular TCN2:RCbl (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
LRP2:LDLRAP1 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
LRP2:LDLRAP1:TCN2:RCbl [plasma membrane] (Canis familiaris)
LRP2:LDLRAP1 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
LRP2:LDLRAP1 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
LRP2:LDLRAP1:TCN2:RCbl [plasma membrane] (Canis familiaris)
LRP2:LDLRAP1 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)
LRPs [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
BAR domain proteins recruit dynamin (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
DAB2 binds LRP2 (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
Clathrin recruits PIK3C2A (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2 [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PKW5
Gene Names
LRP2
Reference Genes
ENSEMBL:ENSCAFG00845021313.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845021313.1 LRP2
Other Identifiers
478781
Cfa.13786.1.A1_s_at
Cfa.17027.1.S1_at
CfaAffx.18972.1.S1_s_at
CfaAffx.19031.1.S1_s_at
GO:0001822
GO:0001843
GO:0003139
GO:0003148
GO:0003223
GO:0003281
GO:0005509
GO:0005515
GO:0005768
GO:0005783
GO:0005794
GO:0005886
GO:0005903
GO:0005905
GO:0006629
GO:0006766
GO:0006897
GO:0006898
GO:0007507
GO:0007605
GO:0008283
GO:0008584
GO:0009897
GO:0012501
GO:0015031
GO:0016020
GO:0016192
GO:0016324
GO:0022414
GO:0023052
GO:0030001
GO:0030139
GO:0030154
GO:0030424
GO:0030425
GO:0030514
GO:0030900
GO:0031410
GO:0031526
GO:0034311
GO:0035904
GO:0042359
GO:0043066
GO:0043226
GO:0043235
GO:0043491
GO:0044321
GO:0045177
GO:0048856
GO:0050769
GO:0050877
GO:0051087
GO:0055085
GO:0060068
GO:0060976
GO:0060982
GO:0061156
GO:0070447
GO:0140058
GO:1904447
Participates
as an input of
DAB2 binds LRP2 (Canis familiaris)
as a component of
LRP2:DAB2 [plasma membrane] (Canis familiaris)
LRP2:LDLRAP1 [plasma membrane] (Canis familiaris)
as a member of
LRPs [plasma membrane] (Canis familiaris)
Other forms of this molecule
LRP2 [clathrin-coated endocytic vesicle membrane]
Inferred From
LRP2 [plasma membrane]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000081479
Ensembl
ENSCAFP00845031349
,
ENSCAFT00845040035
,
ENSCAFG00845021313
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