Reactome | SETD1A [nucleoplasm]

SETD1A [nucleoplasm]

Stable Identifier

R-CFA-3239027

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

SETD1A, A0A8I3NCR0

Locations in the PathwayBrowser

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Gene expression (Transcription) (Canis familiaris)

- Epigenetic regulation of gene expression (Canis familiaris)
  - Formation of WDR5-containing histone-modifying complexes (Canis familiaris)
    - BOD1L1 binds SET1A complex (Canis familiaris)
      - BOD1L1:SET1A complex:WDR82:CXXC1 [nucleoplasm] (Canis familiaris)
        
        SET1A complex:WDR82:CXXC1 [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
      - SET1A complex:WDR82:CXXC1 [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
    - CXXC1 and WDR82 bind SET1A complex (Canis familiaris)
      - SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
      - SET1A complex:WDR82:CXXC1 [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
    - Formation of the SET1A complex (Canis familiaris)
      - SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
      - SETD1A [nucleoplasm] (Canis familiaris)
    - HCFC1 binds SET1A complex (Canis familiaris)
      - SET1A complex:WDR82:CXXC1 [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
      - SET1A complex:WDR82:CXXC1:HCFC1 [nucleoplasm] (Canis familiaris)
        
        SET1A complex:WDR82:CXXC1 [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional regulation by RUNX1 (Canis familiaris)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Canis familiaris)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        SET1A complex [nucleoplasm] (Canis familiaris)
        
        SETD1A [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NCR0

Gene Names

SETD1A

Reference Genes

ENSEMBL:ENSCAFG00845012917.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845012917.1 SETD1A

Other Identifiers

489916

CfaAffx.25619.1.S1_at

GO:0000785

GO:0003676

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006338

GO:0007420

GO:0008013

GO:0008168

GO:0016607

GO:0016740

GO:0030154

GO:0032259

GO:0035097

GO:0036211

GO:0042800

GO:0043226

GO:0048188

GO:0048856

GO:0051568

GO:0061629

GO:0140096

GO:1902036

GO:1902275

Participates

as an input of

Formation of the SET1A complex (Canis familiaris)

as a component of

SET1A complex [nucleoplasm] (Canis familiaris)

Inferred From

SETD1A [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000099381

Ensembl

ENSCAFG00845012917, ENSCAFP00845018010, ENSCAFT00845022975

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