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USP7 [nucleoplasm]
Stable Identifier
R-CFA-3215278
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
USP7, A0A8I3NH60
Locations in the PathwayBrowser
Expand all
DNA Repair (Canis familiaris)
Nucleotide Excision Repair (Canis familiaris)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
Dual incision in TC-NER (Canis familiaris)
3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)
TC-NER incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)
TC-NER incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
ERCC5 and RPA bind TC-NER site (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
Formation of TC-NER Pre-Incision Complex (Canis familiaris)
Assembly of the pre-incision complex in TC-NER (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
Gap-filling DNA repair synthesis and ligation in TC-NER (Canis familiaris)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Expression and Degradation (Canis familiaris)
Regulation of TP53 Degradation (Canis familiaris)
DAXX binds Ub-MDM2 and USP7 (Canis familiaris)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
USP7 deubiquitinates MDM2 (Canis familiaris)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN localization (Canis familiaris)
USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)
USP7 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NH60
Gene Names
USP7
Reference Genes
ENSEMBL:ENSCAFG00845013702.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845013702.1 USP7
Other Identifiers
479854
Cfa.623.1.A1_at
Cfa.623.1.A2_at
CfaAffx.29016.1.S1_s_at
GO:0002039
GO:0003824
GO:0004197
GO:0004843
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0005975
GO:0006281
GO:0006283
GO:0006508
GO:0008233
GO:0008234
GO:0016192
GO:0016579
GO:0016605
GO:0016787
GO:0023052
GO:0030163
GO:0031647
GO:0032435
GO:0032991
GO:0036211
GO:0042752
GO:0043226
GO:0044027
GO:0045721
GO:0050821
GO:0075342
GO:0101005
GO:0140096
GO:1901537
GO:1904262
GO:1905279
GO:1990380
Participates
as a component of
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Canis familiaris)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Canis familiaris)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Canis familiaris)
UVSSA:USP7 [nucleoplasm] (Canis familiaris)
as an output of
USP7 deubiquitinates MDM2 (Canis familiaris)
as an input of
DAXX binds Ub-MDM2 and USP7 (Canis familiaris)
Other forms of this molecule
USP7 [cytosol]
Inferred From
USP7 [nucleoplasm]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000187555
Ensembl
ENSCAFG00845013702
,
ENSCAFT00845024561
,
ENSCAFP00845019320
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