Reactome | MCM8 [nucleoplasm]

MCM8 [nucleoplasm]

Stable Identifier

R-CFA-3006646

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

MCM8, A0A8I3SAR8

Locations in the PathwayBrowser

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Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - G2/M Checkpoints (Canis familiaris)
    - Activation of ATR in response to replication stress (Canis familiaris)
      - Activation of claspin (Canis familiaris)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
      - Loading of claspin onto DNA during replication origin firing (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
- Cell Cycle, Mitotic (Canis familiaris)
  - Mitotic G1 phase and G1/S transition (Canis familiaris)
    - G1/S Transition (Canis familiaris)
      - Activation of the pre-replicative complex (Canis familiaris)
        
        Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        Cdt1 is displaced from the pre-replicative complex. (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM10:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        DNA polymerase alpha:primase binds at the origin (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        DNA polymerase epsilon binds at the origin (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
  - S Phase (Canis familiaris)
    - Synthesis of DNA (Canis familiaris)
      - Switching of origins to a post-replicative state (Canis familiaris)
        
        Orc1 removal from chromatin (Canis familiaris)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)

DNA Replication (Canis familiaris)

- DNA Replication Pre-Initiation (Canis familiaris)
  - Activation of the pre-replicative complex (Canis familiaris)
    - Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
    - Cdt1 is displaced from the pre-replicative complex. (Canis familiaris)
      - MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
      - MCM10:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
    - DNA polymerase alpha:primase binds at the origin (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
    - DNA polymerase epsilon binds at the origin (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
  - Assembly of the pre-replicative complex (Canis familiaris)
    - CDC6 association with the ORC:origin complex (Canis familiaris)
      - CDC6 association with ORC(1-6) at replication origins (Canis familiaris)
        
        CDC6:MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
      - MCM8 binds CDC6 (Canis familiaris)
        
        CDC6:MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
- Synthesis of DNA (Canis familiaris)
  - Switching of origins to a post-replicative state (Canis familiaris)
    - Orc1 removal from chromatin (Canis familiaris)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)
        
        pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        Orc2 associated with MCM8 [nucleoplasm] (Canis familiaris)
        
        MCM8 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3SAR8

Gene Names

MCM8

Reference Genes

ENSEMBL:ENSCAFG00845027289.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845027289.1 MCM8

Other Identifiers

477163

607530

Cfa.6086.1.A1_s_at

GO:0000724

GO:0003677

GO:0003682

GO:0003824

GO:0005524

GO:0005634

GO:0006281

GO:0006310

GO:0006974

GO:0007292

GO:0016787

GO:0016887

GO:0019899

GO:0022414

GO:0032406

GO:0032407

GO:0032408

GO:0032508

GO:0036298

GO:0043226

GO:0048232

GO:0050821

GO:0071168

GO:0097362

GO:0140657

Participates

as an input of

MCM8 binds CDC6 (Canis familiaris)

as a component of

Inferred From

MCM8 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000125885

Ensembl

ENSCAFG00845027289, ENSCAFP00845037812, ENSCAFT00845048207

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