Reactome | ITPR2 [endoplasmic reticulum membrane]

ITPR2 [endoplasmic reticulum membrane]

Stable Identifier

R-CFA-3006467

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

endoplasmic reticulum membrane

Synonyms

ITPR2, A0A8I3PW88

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Signaling by the B Cell Receptor (BCR) (Canis familiaris)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
      - STIM1 oligomerizes (Canis familiaris)
        
        ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Canis familiaris)
        
        Ca-channel (closed) [endoplasmic reticulum membrane] (Canis familiaris)
        
        IP3-gated Ca-channel type 2 [endoplasmic reticulum membrane] (Canis familiaris)
        
        ITPR2 [endoplasmic reticulum membrane] (Canis familiaris)

Muscle contraction (Canis familiaris)

- Cardiac conduction (Canis familiaris)
  - Ion homeostasis (Canis familiaris)
    - AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Canis familiaris)
      - AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Canis familiaris)
        
        ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Canis familiaris)
        
        Ca-channel (closed) [endoplasmic reticulum membrane] (Canis familiaris)
        
        IP3-gated Ca-channel type 2 [endoplasmic reticulum membrane] (Canis familiaris)
        
        ITPR2 [endoplasmic reticulum membrane] (Canis familiaris)
      - ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Canis familiaris)
        
        Ca-channel (closed) [endoplasmic reticulum membrane] (Canis familiaris)
        
        IP3-gated Ca-channel type 2 [endoplasmic reticulum membrane] (Canis familiaris)
        
        ITPR2 [endoplasmic reticulum membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PW88

Gene Names

ITPR2

Reference Genes

ENSEMBL:ENSCAFG00845025705.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845025705.1 ITPR2

Other Identifiers

486628

Cfa.14076.1.A1_at

CfaAffx.17678.1.S1_s_at

GO:0001666

GO:0005215

GO:0005216

GO:0005220

GO:0005262

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005886

GO:0005938

GO:0006811

GO:0006816

GO:0008289

GO:0012505

GO:0015278

GO:0016020

GO:0016529

GO:0023052

GO:0033017

GO:0034220

GO:0035091

GO:0043226

GO:0043231

GO:0043235

GO:0044325

GO:0051209

GO:0055065

GO:0055085

GO:0070588

GO:0070679

GO:0071320

GO:0071361

GO:0097110

Participates

as a component of

Other forms of this molecule

ITPR2 [platelet dense tubular network membrane]

Inferred From

ITPR2 [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000123104

Ensembl

ENSCAFT00845045427, ENSCAFP00845035630, ENSCAFG00845025705