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SMAD2 [cytosol]
Stable Identifier
R-CFA-3006353
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
SMAD2, A0A8I3MFT9
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Canis familiaris)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by Activin (Canis familiaris)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
Degradation of ubiquitinated SMAD2 (Canis familiaris)
Ub-SMAD2 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
PMEPA1 sequesters unphosphorylated SMAD2/3 (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
SMAD2/3:PMEPA1 [plasma membrane] (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
SMURF2 binds SMAD2 (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
SMAD2:SMURF2 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
SMURF2 ubiquitinates SMAD2 (Canis familiaris)
SMAD2:SMURF2 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
Ub-SMAD2 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MFT9
Gene Names
SMAD2
Reference Genes
BioGPS Gene:480144 SMAD2
ENSEMBL:ENSCAFG00845002338.1
Monarch:480144 SMAD2
NCBI Gene:480144 SMAD2
UCSC:A0A8I3MFT9 SMAD2
Reference Transcript
RefSeq:XM_847706.4 SMAD2
RefSeq:XM_014115427.1 SMAD2
RefSeq:XM_005622830.2 SMAD2
Other Identifiers
CfaAffx.26872.1.S1_s_at
CfaAffx.26880.1.S1_s_at
GO:0000785
GO:0000978
GO:0000981
GO:0001228
GO:0001657
GO:0001701
GO:0001706
GO:0001707
GO:0003140
GO:0003180
GO:0003184
GO:0003203
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005160
GO:0005634
GO:0005667
GO:0005737
GO:0006355
GO:0007179
GO:0007352
GO:0007369
GO:0007389
GO:0007492
GO:0007507
GO:0008092
GO:0008283
GO:0009653
GO:0009749
GO:0009791
GO:0009880
GO:0009952
GO:0010628
GO:0010629
GO:0010718
GO:0017015
GO:0019902
GO:0030073
GO:0030154
GO:0030324
GO:0030513
GO:0031016
GO:0031625
GO:0032444
GO:0032924
GO:0032991
GO:0034713
GO:0035265
GO:0035556
GO:0038092
GO:0042802
GO:0043226
GO:0045165
GO:0045892
GO:0045893
GO:0045944
GO:0046332
GO:0046872
GO:0048156
GO:0048340
GO:0048589
GO:0048617
GO:0048701
GO:0048856
GO:0060039
GO:0060395
GO:0061629
GO:0062009
GO:0070410
GO:0070411
GO:0070412
GO:0070723
GO:0071141
GO:0071142
GO:0071144
GO:0071559
GO:0071895
GO:0097718
GO:0140110
GO:0140297
Participates
as a member of
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
as a component of
Ub-SMAD2 [cytosol] (Canis familiaris)
SMAD2:SMURF2 [cytosol] (Canis familiaris)
as an input of
SMURF2 binds SMAD2 (Canis familiaris)
Other forms of this molecule
SMAD2 [cytosol]
phospho-SMAD2 [cytosol]
SMAD2 [nucleoplasm]
phospho-SMAD2 [nucleoplasm]
phospho-SMAD2 [nucleoplasm]
phospho-SMAD2 [cytosol]
phospho-SMAD2 [nucleoplasm]
Inferred From
SMAD2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_013970902.1
,
XP_852799.1
,
XP_005622887.1
ENSEMBL
ENSCAFP00845003314
,
ENSCAFT00845004143
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