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GSK3B [cytosol]
Stable Identifier
R-CFA-2997551
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
GSK3B, A0A8I3P4F2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
Constitutive phosphorylation by GSK3 (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
Semaphorin interactions (Canis familiaris)
CRMPs in Sema3A signaling (Canis familiaris)
Phosphorylation of CRMPs by GSK3beta (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'off' state (Canis familiaris)
GLI3 is processed to GLI3R by the proteasome (Canis familiaris)
GSK3 phosphorylates p-GLI3 (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Signaling by WNT (Canis familiaris)
Degradation of beta-catenin by the destruction complex (Canis familiaris)
AXIN is phosphorylated in the destruction complex (Canis familiaris)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Assembly of the destruction complex (Canis familiaris)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Canis familiaris)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Association of beta-catenin with the destruction complex (Canis familiaris)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Beta-catenin phosphorylation cascade (Canis familiaris)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Canis familiaris)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Canis familiaris)
FRAT1,2:GSK3beta [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Canis familiaris)
FRAT1,2:GSK3beta [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Canis familiaris)
FRAT1,2:GSK3beta [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Degradation of ubiquitinated beta catenin by the proteasome (Canis familiaris)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Canis familiaris)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Canis familiaris)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Canis familiaris)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Phosphorylation of APC component of the destruction complex (Canis familiaris)
CK1alpha (GSK3) [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
TCF dependent signaling in response to WNT (Canis familiaris)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Canis familiaris)
Beta-catenin is released from the destruction complex (Canis familiaris)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
GSK3B:AXIN1 [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Canis familiaris)
GSK3B:AXIN1 [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Canis familiaris)
GSK3B:AXIN1 [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Canis familiaris)
GSK3B:AXIN1 [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
FRAT proteins bind GSK3beta (Canis familiaris)
FRAT1,2:GSK3beta [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Canis familiaris)
GSK3B:AXIN1 [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Canis familiaris)
GSK3B:AXIN1 [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Canis familiaris)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [early endosome membrane] (Canis familiaris)
GSK3B:AXIN1 [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Canis familiaris)
GSK3B:AXIN1 [cytosol] (Canis familiaris)
GSK3B [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3P4F2
Gene Names
GSK3B
Reference Genes
ENSEMBL:ENSCAFG00845017754.1
UCSC:A0A8I3P4F2 GSK3B
Other Identifiers
Cfa.913.1.A1_s_at
Cfa.913.2.A1_at
GO:0001837
GO:0001954
GO:0002020
GO:0002039
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005886
GO:0005975
GO:0005977
GO:0006091
GO:0006983
GO:0007005
GO:0008013
GO:0008092
GO:0008286
GO:0009968
GO:0010628
GO:0010629
GO:0010719
GO:0010975
GO:0016301
GO:0016740
GO:0019901
GO:0021766
GO:0030154
GO:0030336
GO:0030424
GO:0030877
GO:0031175
GO:0031333
GO:0031334
GO:0031398
GO:0031625
GO:0032436
GO:0032886
GO:0034236
GO:0034452
GO:0035556
GO:0043066
GO:0043226
GO:0045597
GO:0045668
GO:0046825
GO:0046827
GO:0048856
GO:0050321
GO:0051059
GO:0051093
GO:0051128
GO:0060070
GO:0061629
GO:0070507
GO:0070885
GO:0071109
GO:0071300
GO:0090090
GO:0097192
GO:0098793
GO:0098978
GO:0099171
GO:0106310
GO:0140096
GO:0150101
GO:1902042
GO:1904781
GO:2000740
Participates
as a component of
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
FRAT1,2:GSK3beta [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
GSK3B:AXIN1 [cytosol] (Canis familiaris)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
as an input of
Assembly of the destruction complex (Canis familiaris)
FRAT proteins bind GSK3beta (Canis familiaris)
as a candidate of
CK1alpha (GSK3) [cytosol] (Canis familiaris)
Other forms of this molecule
GSK3B [nucleoplasm]
Inferred From
GSK3B [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845024619
,
ENSCAFT00845031438
,
ENSCAFG00845017754
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