Reactome | EFNA1 [plasma membrane]

EFNA1 [plasma membrane]

Stable Identifier

R-CFA-2682339

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

EFNA1, A0A8I3NS68

Locations in the PathwayBrowser

Expand all

Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - EPH-Ephrin signaling (Canis familiaris)
      - EPH receptors autophosphorylate (Canis familiaris)
        
        EPH-ephrin oligomers [plasma membrane] (Canis familiaris)
        
        EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
      - EPH-ephrin mediated repulsion of cells (Canis familiaris)
        
        EPHA binds TIAM1 (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        SFKs phosphorylate VAV2,3 (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        p-EPHs bind VAV2,3 (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
      - EPH:EFN dimers tetramerise (Canis familiaris)
        
        EPH-EFN dimers [plasma membrane] (Canis familiaris)
        
        EPHA:EFNA dimers [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
      - EPH:EFN tetramers oligomerise (Canis familiaris)
        
        EPH-EFN dimers [plasma membrane] (Canis familiaris)
        
        EPHA:EFNA dimers [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        EPH-ephrin oligomers [plasma membrane] (Canis familiaris)
        
        EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
      - EPHA-mediated growth cone collapse (Canis familiaris)
        
        NGEF exchanges GTP for GDP on RHOA (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Canis familiaris)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
      - EPHAs bind EFNAs (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs [plasma membrane] (Canis familiaris)
        
        EFNAs [plasma membrane] (Canis familiaris)
        
        EFNA1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NS68

Gene Names

EFNA1

Reference Genes

ENSEMBL:ENSCAFG00845013438.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845013438.1 EFNA1

Other Identifiers

490431

Cfa.21286.1.S1_at

CfaAffx.26111.1.S1_at

GO:0000122

GO:0001934

GO:0003180

GO:0003183

GO:0003199

GO:0005886

GO:0006351

GO:0006355

GO:0007155

GO:0010719

GO:0012501

GO:0014028

GO:0016020

GO:0016477

GO:0023052

GO:0030154

GO:0030163

GO:0030182

GO:0033628

GO:0034330

GO:0034446

GO:0036211

GO:0043409

GO:0043410

GO:0043535

GO:0045765

GO:0046875

GO:0048013

GO:0048856

GO:0048870

GO:0050730

GO:0050731

GO:0050770

GO:0050821

GO:0061002

GO:0070244

GO:0098552

GO:1902004

GO:1903051

Participates

as a member of

EFNAs [plasma membrane] (Canis familiaris)

Inferred From

EFNA1 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000169242

Ensembl

ENSCAFT00845023961, ENSCAFP00845018817, ENSCAFG00845013438

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