NPC1L1-mediated cholesterol uptake

Stable Identifier
R-CFA-265529
Type
Reaction [transition]
Species
Canis familiaris
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
NPC1L1-mediated cholesterol uptake
Dietary cholesterol is taken up into enterocytes from the gut lumen in a reaction mediated by plasma membrane-associated NPC1L1 protein. Detailed studies in Maden-Darby canine kidney cells, both mediated by endogenous (canine) NPC1L1 and by overexpressed human protein, indicate a major role for NPC1L1 in the uptake of extracellular cholesterol. These studies have also shown that ezetimibe binds both human and canine proteins and renders them incapable of mediating cholesterol uptake. The molecular mechanisms of cholesterol transport and ezetimibe inhibition, however, remain unclear (Weinglass et al. 2008).
Literature References
PubMed ID Title Journal Year
18187582 Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake

Beers, L, Nketiah, EO, Thomas, A, Schmalhofer, W, Williams, B, Köhler, MG, Bleasby, K, Leone, J, Hafey, M, Smith, L, Kaczorowski, GJ, Garcia, ML, Braun, MP, Tang, YS, Ujjainwalla, F, Liu, J, McCann, ME, Weinglass, AB

Mol Pharmacol 2008
Participants
Catalyst Activity

cholesterol transfer activity of NPC1L1 [plasma membrane]

This event is regulated
Orthologous Events
Authored
Reviewed
Created
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