Reactome | NPC1L1-mediated cholesterol uptake

NPC1L1-mediated cholesterol uptake

Stable Identifier

R-CFA-265529

Type

Reaction [transition]

Species

Canis familiaris

Compartment

plasma membrane

ReviewStatus

5/5

General

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Dietary cholesterol is taken up into enterocytes from the gut lumen in a reaction mediated by plasma membrane-associated NPC1L1 protein. Detailed studies in Maden-Darby canine kidney cells, both mediated by endogenous (canine) NPC1L1 and by overexpressed human protein, indicate a major role for NPC1L1 in the uptake of extracellular cholesterol. These studies have also shown that ezetimibe binds both human and canine proteins and renders them incapable of mediating cholesterol uptake. The molecular mechanisms of cholesterol transport and ezetimibe inhibition, however, remain unclear (Weinglass et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18187582	Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake Beers, L, Nketiah, EO, Thomas, A, Schmalhofer, W, Williams, B, Köhler, MG, Bleasby, K, Leone, J, Hafey, M, Smith, L, Kaczorowski, GJ, Garcia, ML, Braun, MP, Tang, YS, Ujjainwalla, F, Liu, J, McCann, ME, Weinglass, AB	Mol Pharmacol	2008