Reactome | SMC1A [chromosome, centromeric region]

SMC1A [chromosome, centromeric region]

Stable Identifier

R-CFA-2466015

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

chromosome, centromeric region

Synonyms

SMC1A, A0A8I3Q022

Locations in the PathwayBrowser

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Cell Cycle (Canis familiaris)

- Cell Cycle, Mitotic (Canis familiaris)
  - M Phase (Canis familiaris)
    - Mitotic Metaphase and Anaphase (Canis familiaris)
      - Mitotic Anaphase (Canis familiaris)
        
        Separation of Sister Chromatids (Canis familiaris)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Cleaved Cohesin [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        p-RAD21-Ac-Cohesin [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
        
        Separation of sister chromatids (Canis familiaris)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Cleaved Cohesin [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
    - Mitotic Prometaphase (Canis familiaris)
      - Resolution of Sister Chromatid Cohesion (Canis familiaris)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore assembly (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Canis familiaris)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        p-RAD21-Ac-Cohesin [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)
  - S Phase (Canis familiaris)
    - Establishment of Sister Chromatid Cohesion (Canis familiaris)
      - CDCA5 (Sororin) enables cohesion of sister centromeres (Canis familiaris)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Canis familiaris)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Canis familiaris)
        
        SMC1A [chromosome, centromeric region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q022

Gene Names

SMC1A

Reference Genes

BioGPS Gene:480928 SMC1A

ENSEMBL:ENSCAFG00845029049.1

Monarch:480928 SMC1A

NCBI Gene:480928 SMC1A

UCSC:A0A8I3Q022 SMC1A

Reference Transcript

RefSeq:XM_538049.4 SMC1A

Other Identifiers

CfaAffx.24935.1.S1_at

CfaAffx.24935.1.S1_s_at

GO:0000776

GO:0003677

GO:0003682

GO:0003824

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0007010

GO:0007062

GO:0008278

GO:0009314

GO:0016363

GO:0016787

GO:0016887

GO:0022414

GO:0030892

GO:0030893

GO:0035019

GO:0036033

GO:0043226

GO:0046982

GO:0051321

GO:0072423

GO:0090307

GO:0097431

Participates

as a component of

Other forms of this molecule

SMC1A [cytosol]

SMC1A [chromosome]

SMC1A [nucleoplasm]

Inferred From

SMC1A [chromosome, centromeric region] (Homo sapiens)

Cross References

RefSeq

XP_538049.3

ENSEMBL

ENSCAFG00845029049, ENSCAFP00845040515, ENSCAFT00845051637

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