Reactome | KLRD1 [plasma membrane]

KLRD1 [plasma membrane]

Stable Identifier

R-CFA-2326854

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

KLRD1, Q38HS3

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - DAP12 interactions (Canis familiaris)
    - DAP12 interacts with NKG2C (Canis familiaris)
      - CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
      - HLA-E:CD94:NKG2C:DAP12 [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
    - DAP12 signaling (Canis familiaris)
      - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
      - Phosphorylation of BTK by p-SYK (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
      - Phosphorylation of LAT by p-SYK (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
        
        p-SYK/p-BTK [plasma membrane] (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
      - Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
      - Phosphorylation of SYK (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
      - Recruitment of SYK to p-DAP12 (Canis familiaris)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Canis familiaris)
        
        DAP12 receptors [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Canis familiaris)
        
        CD94:NKG2C [plasma membrane] (Canis familiaris)
        
        KLRD1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:Q38HS3

Gene Names

KLRD1

Reference Genes

BioGPS Gene:611360 KLRD1

ENSEMBL:ENSCAFG00030019329

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000013459.6 KLRD1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030019329.1 KLRD1

KEGG Gene (Canis lupus familiaris):611360 KLRD1

Monarch:611360 KLRD1

NCBI Gene:611360 KLRD1

Reference Transcript

Participates

as a component of

CD94:NKG2C [plasma membrane] (Canis familiaris)

Inferred From

KLRD1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001041500.1, XP_005636778.1

OpenTargets

ENSG00000134539

VGNC

42486

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