Reactome | HLA-DQB1 [lysosomal membrane]

HLA-DQB1 [lysosomal membrane]

Stable Identifier

R-CFA-2130385-2

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

lysosomal membrane

Synonyms

HLA class II histocompatibility antigen, DQ beta 2 chain, F6V690

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - MHC class II antigen presentation (Canis familiaris)
    - Cleavage of lip22 to lip10 (Canis familiaris)
      - MHC II:lip10 nonamer [lysosomal membrane] (Canis familiaris)
        
        MHC II alpha/beta dimer [lysosomal membrane] (Canis familiaris)
        
        HLA II beta chain [lysosomal membrane] (Canis familiaris)
        
        Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain [lysosomal membrane] (Canis familiaris)
        
        HLA-DQB1 [lysosomal membrane] (Canis familiaris)
      - MHC II:lip22 nonamer [lysosomal membrane] (Canis familiaris)
        
        MHC II alpha/beta dimer [lysosomal membrane] (Canis familiaris)
        
        HLA II beta chain [lysosomal membrane] (Canis familiaris)
        
        Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain [lysosomal membrane] (Canis familiaris)
        
        HLA-DQB1 [lysosomal membrane] (Canis familiaris)
    - Generation of CLIP from lip10 (Canis familiaris)
      - MHC II:CLIP [lysosomal membrane] (Canis familiaris)
        
        MHC II alpha/beta dimer [lysosomal membrane] (Canis familiaris)
        
        HLA II beta chain [lysosomal membrane] (Canis familiaris)
        
        Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain [lysosomal membrane] (Canis familiaris)
        
        HLA-DQB1 [lysosomal membrane] (Canis familiaris)
      - MHC II:lip10 nonamer [lysosomal membrane] (Canis familiaris)
        
        MHC II alpha/beta dimer [lysosomal membrane] (Canis familiaris)
        
        HLA II beta chain [lysosomal membrane] (Canis familiaris)
        
        Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain [lysosomal membrane] (Canis familiaris)
        
        HLA-DQB1 [lysosomal membrane] (Canis familiaris)
    - Initial proteolyis of Ii by aspartic proteases to lip22 (Canis familiaris)
      - MHC II:lip22 nonamer [lysosomal membrane] (Canis familiaris)
        
        MHC II alpha/beta dimer [lysosomal membrane] (Canis familiaris)
        
        HLA II beta chain [lysosomal membrane] (Canis familiaris)
        
        Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain [lysosomal membrane] (Canis familiaris)
        
        HLA-DQB1 [lysosomal membrane] (Canis familiaris)
      - Nonameric complex [lysosomal membrane] (Canis familiaris)
        
        MHC II alpha/beta dimer [lysosomal membrane] (Canis familiaris)
        
        HLA II beta chain [lysosomal membrane] (Canis familiaris)
        
        Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain [lysosomal membrane] (Canis familiaris)
        
        HLA-DQB1 [lysosomal membrane] (Canis familiaris)
    - TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Canis familiaris)
      - Nonameric complex [lysosomal membrane] (Canis familiaris)
        
        MHC II alpha/beta dimer [lysosomal membrane] (Canis familiaris)
        
        HLA II beta chain [lysosomal membrane] (Canis familiaris)
        
        Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain [lysosomal membrane] (Canis familiaris)
        
        HLA-DQB1 [lysosomal membrane] (Canis familiaris)
    - Trafficking of nonameric complex in the endocytic pathway (Canis familiaris)
      - Nonameric complex [lysosomal membrane] (Canis familiaris)
        
        MHC II alpha/beta dimer [lysosomal membrane] (Canis familiaris)
        
        HLA II beta chain [lysosomal membrane] (Canis familiaris)
        
        Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain [lysosomal membrane] (Canis familiaris)
        
        HLA-DQB1 [lysosomal membrane] (Canis familiaris)
    - Transport of antigen loaded MHC II molecules to surface (Canis familiaris)
      - peptide loaded MHC class II [lysosomal membrane] (Canis familiaris)
        
        MHC II alpha/beta dimer [lysosomal membrane] (Canis familiaris)
        
        HLA II beta chain [lysosomal membrane] (Canis familiaris)
        
        Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain [lysosomal membrane] (Canis familiaris)
        
        HLA-DQB1 [lysosomal membrane] (Canis familiaris)