Reactome | COL4A1 [extracellular region]

COL4A1 [extracellular region]

Stable Identifier

R-CFA-2127419

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL4A1(173-1669), A0A8I3S0U4

Locations in the PathwayBrowser

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Extracellular matrix organization (Canis familiaris)

- Collagen formation (Canis familiaris)
  - Assembly of collagen fibrils and other multimeric structures (Canis familiaris)
    - Crosslinking of collagen fibrils (Canis familiaris)
      - Collagen type IV sulfilimine cross-linking by peroxidasin (Canis familiaris)
        
        Collagen IV [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Collagen type IV networks with sulfilimine cross-links [extracellular region] (Canis familiaris)
        
        Sulfilimine-containing collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) with or without sulfiliminyl cross-links [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Sulfilimine-containing collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens with or without sulfilimine cross-links [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) with or without sulfiliminyl cross-links [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
    - Formation of collagen networks (Canis familiaris)
      - Collagen networks [extracellular region] (Canis familiaris)
        
        Collagen IV [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
      - Network forming tropocollagens [extracellular region] (Canis familiaris)
        
        Tropocollagen type IV [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
- Degradation of the extracellular matrix (Canis familiaris)
  - Collagen degradation (Canis familiaris)
    - Collagen type IV degradation by MMP2,3,4,9,10,12 (Canis familiaris)
      - Collagen IV [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
- FN1 binds Collagen types I-V, VII (Canis familiaris)
  - Collagen types I-V, VII [extracellular region] (Canis familiaris)
    - Collagen IV [extracellular region] (Canis familiaris)
      - Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
  - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Canis familiaris)
    - Collagen types I-V, VII [extracellular region] (Canis familiaris)
      - Collagen IV [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
- Integrin cell surface interactions (Canis familiaris)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Canis familiaris)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Canis familiaris)
      - Collagen IV [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Canis familiaris)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Canis familiaris)
        
        Collagen IV [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
- Laminin interactions (Canis familiaris)
  - Laminins:Nidogens binds collagen type IV networks (Canis familiaris)
    - Collagen IV [extracellular region] (Canis familiaris)
      - Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
    - Laminins with gamma-1, gamma-3:Nidogens:Collagen type IV network [extracellular region] (Canis familiaris)
      - Collagen IV [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
- Non-integrin membrane-ECM interactions (Canis familiaris)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Canis familiaris)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Canis familiaris)
      - Collagen IV [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Canis familiaris)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Canis familiaris)
        
        Collagen IV [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Canis familiaris)
        
        COL4A1 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S0U4

Gene Names

COL4A1

Reference Genes

ENSEMBL:ENSCAFG00845018797.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845018797.1 COL4A1

Other Identifiers

403496

Cfa.15297.1.A1_at

Cfa.17376.1.S1_s_at

Cfa.208.1.A1_at

CfaAffx.10085.1.S1_s_at

GO:0001569

GO:0005198

GO:0005201

GO:0005581

GO:0005587

GO:0005604

GO:0007420

GO:0007528

GO:0023052

GO:0030020

GO:0030198

GO:0030312

GO:0031012

GO:0034330

GO:0038063

GO:0048407

GO:0048514

GO:0048856

GO:0061304

GO:0061333

GO:0071230

GO:0071711

Participates

as a component of

Other forms of this molecule

COL4A1 [endoplasmic reticulum lumen]

COL4A1 [extracellular region]

Inferred From

Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)

3x4Hyp-3Hyp-GalHyl-COL4A1(173-1669) [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

OpenTargets

ENSG00000187498

Ensembl

ENSCAFT00845033606, ENSCAFG00845018797, ENSCAFP00845026310

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