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What is Reactome ?
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A0A8I3P4Y5 [plasma membrane]
Stable Identifier
R-CFA-2038878-5
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
BLNK (SLP-65) Signalosome [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
BTK binds BTK inhibitors (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
BTK:BTK inhibitors [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
SYK autophosphorylates at the activated BCR (Canis familiaris)
Antigen:p-BCR:SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
SYK binds the activated BCR (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
The Immunoglobulin of the BCR binds antigen (Canis familiaris)
Antigen:BCR [plasma membrane] (Canis familiaris)
BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
CD22 mediated BCR regulation (Canis familiaris)
CD22 binds B-cell receptor (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
CD22:Antigen:p-BCR [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
LYN phosphorylates CD22 (Canis familiaris)
CD22:Antigen:p-BCR [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
SHP1 binds p-CD22 (Canis familiaris)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Canis familiaris)
Antigen:p-BCR [plasma membrane] (Canis familiaris)
p-BCR [plasma membrane] (Canis familiaris)
IgM or IgD [plasma membrane] (Canis familiaris)
IgD [plasma membrane] (Canis familiaris)
IgD Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
IgM [plasma membrane] (Canis familiaris)
IgM Heavy Chain [plasma membrane] (Canis familiaris)
Ig Heavy Chain V Region [plasma membrane] (Canis familiaris)
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
A0A8I3P4Y5 [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3P4Y5
Reference Genes
ENSEMBL:ENSCAFG00845018946.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845018946.1
Other Identifiers
CfaAffx.539.1.S1_x_at
Participates
as a member of
Homologues of Ig heavy chain V-III region BRO [plasma membrane] (Canis familiaris)
Other forms of this molecule
IgH heavy chain V-III region VH26 precursor [plasma membrane]
IgH heavy chain V-III region VH26 precursor [extracellular region]
A0A8I3P4Y5 [extracellular region]
Inferred From
Ig heavy chain V-III region KOL [plasma membrane]
(Homo sapiens)
Ig heavy chain V-III region JON [plasma membrane]
(Homo sapiens)
Ig heavy chain V-III region DOB [plasma membrane]
(Homo sapiens)
Ig heavy chain V-III region WEA [plasma membrane]
(Homo sapiens)
Ig heavy chain V-III region BUT [plasma membrane]
(Homo sapiens)
Ig heavy chain V-III region CAM [plasma membrane]
(Homo sapiens)
Ig heavy chain V-III region BRO [plasma membrane]
(Homo sapiens)
Cross References
Ensembl
ENSCAFP00845026174
,
ENSCAFG00845018946
,
ENSCAFT00845033434
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