Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
GRB2 [plasma membrane]
Stable Identifier
R-CFA-202993
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
GRB2-1, A0A8I3PT69
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
BLNK (SLP-65) Signalosome [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Canis familiaris)
GRB2 [plasma membrane] (Canis familiaris)
BTK binds BTK inhibitors (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Canis familiaris)
GRB2 [plasma membrane] (Canis familiaris)
BTK:BTK inhibitors [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Canis familiaris)
GRB2 [plasma membrane] (Canis familiaris)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
CD19 Signalosome [plasma membrane] (Canis familiaris)
GRB2 [plasma membrane] (Canis familiaris)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Canis familiaris)
GRB2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Canis familiaris)
GRB2 [plasma membrane] (Canis familiaris)
p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Canis familiaris)
GRB2 [plasma membrane] (Canis familiaris)
p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)
CD19 Signalosome [plasma membrane] (Canis familiaris)
GRB2 [plasma membrane] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
CD19 Signalosome [plasma membrane] (Canis familiaris)
GRB2 [plasma membrane] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
CD19 Signalosome [plasma membrane] (Canis familiaris)
GRB2 [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PT69
Gene Names
GRB2
Reference Genes
BioGPS Gene:483312 GRB2
ENSEMBL:ENSCAFG00845026938.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026938.1 GRB2
KEGG Gene (Canis lupus familiaris):483312 GRB2
Monarch:483312 GRB2
NCBI Gene:483312 GRB2
Reference Transcript
RefSeq:XM_540431.5 GRB2
Other Identifiers
483312
Cfa.16367.1.A1_at
Cfa.2172.1.S1_at
CfaAffx.8081.1.S1_s_at
GO:0001784
GO:0002376
GO:0005068
GO:0005091
GO:0005154
GO:0005168
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005768
GO:0005886
GO:0005911
GO:0005938
GO:0007010
GO:0007173
GO:0008180
GO:0008286
GO:0008543
GO:0012506
GO:0014044
GO:0016020
GO:0016192
GO:0017124
GO:0019901
GO:0019903
GO:0019904
GO:0023052
GO:0030036
GO:0030154
GO:0030674
GO:0030838
GO:0031410
GO:0031623
GO:0035987
GO:0042552
GO:0042770
GO:0042802
GO:0043226
GO:0043408
GO:0043560
GO:0046875
GO:0048009
GO:0048646
GO:0048856
GO:0050853
GO:0060090
GO:0060670
GO:0065003
GO:0070436
GO:0071479
GO:0098772
GO:2000379
Participates
as a component of
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Canis familiaris)
CD19 Signalosome [plasma membrane] (Canis familiaris)
Other forms of this molecule
GRB2 [cytosol]
Inferred From
GRB2-1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_540431.2
OpenTargets
ENSG00000177885
Ensembl
ENSCAFG00845026938
,
ENSCAFP00845037253
,
ENSCAFT00845047482
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text